| Gene Symbol |
SCNN1B
|
| Entrez Gene |
6338
|
| Alt Symbol |
BESC1, ENaCb, ENaCbeta, SCNEB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sodium channel, non voltage gated 1 beta subunit
|
| Other Description |
amiloride-sensitive sodium channel subunit beta|amiloride-sensitive sodium channel subunit beta 1|beta-ENaC|beta-NaCH|epithelial Na(+) channel subunit beta|epithelial sodium channel beta-2 subunit|epithelial sodium channel beta-3 subunit|nasal epithelial sodium channel beta subunit|nonvoltage-gated sodium channel 1 subunit beta|sodium channel, non-voltage-gated 1, beta subunit|sodium channel, nonvoltage-gated 1, beta
|
| Swissprots |
Q96KG2 Q9UMU5 O60891 C5HTZ2 Q9UJ32 P51168
|
| Accessions |
AAA67036 AAL48196 AAL48197 ACS13723 ACS13724 CAA06508 EAW55833 EAW55834 P51168 AF260226 AAK49394 AK313192 BAG36009 AU105979 BC036352 AAH36352 DQ402523 ABD72219 EU831785 ACE87303 EU831863 ACE86622 HQ257906 ADR82661 L36593 AAA75459 X87159 CAA60632 XM_011545913 XP_011544215 XM_011545914 XP_011544216 NM_000336 NP_000327
|
| Function |
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:24124190}.
|
| Subcellular Location |
Apical cell membrane {ECO:0000269|PubMed:24124190}; Multi-pass membrane protein {ECO:0000269|PubMed:24124190}. Note=Apical membrane of epithelial cells.
|
| Tissue Specificity |
Expressed in kidney (at protein level). {ECO:0000269|PubMed:22207244}.
|
| Top Pathways |
Taste transduction, Aldosterone-regulated sodium reabsorption
|