| Gene Symbol | Mcts1 |
|---|---|
| Entrez Gene | 68995 |
| Alt Symbol | 1500019M23Rik, MCT-1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | malignant T cell amplified sequence 1 |
| Other Description | malignant T cell-amplified sequence 1|malignant T-cell-amplified sequence 1|multiple copies T-cell malignancies 1 |
| Swissprots | Q9DB27 Q3UUI6 |
| Accessions | EDL29020 EDL29021 EDL29022 EDL29023 EDL29024 Q9DB27 AK005292 BAB23936 AK087975 BAC40069 AK138385 BAE23639 BC010486 AAH10486 BC037103 XM_006541534 XP_006541597 XM_006541535 XP_006541598 XM_006541536 XP_006541599 NM_026902 NP_081178 |
| Function | Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up- regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosph |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
Malignant T cell-amplified sequence 1, Mcts1, Mouse, ELISA Kit - E15021m from ARP American Research Products
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malignant T cell amplified sequence 1, ELISA Kit - MBS9323994 from MyBioSource
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Mouse Mcts1 ELISA Kit - E059413 from Biobool
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Mouse Malignant T cell-amplified sequence 1 (MCTS1) ELISA Kit - AE33977MO from ARP American Research Products
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Malignant T cell-amplified sequence 1, ELISA Kit - MBS2884986 from MyBioSource
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