Gene Symbol | Mcts1 |
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Entrez Gene | 68995 |
Alt Symbol | 1500019M23Rik, MCT-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | malignant T cell amplified sequence 1 |
Other Description | malignant T cell-amplified sequence 1|malignant T-cell-amplified sequence 1|multiple copies T-cell malignancies 1 |
Swissprots | Q9DB27 Q3UUI6 |
Accessions | EDL29020 EDL29021 EDL29022 EDL29023 EDL29024 Q9DB27 AK005292 BAB23936 AK087975 BAC40069 AK138385 BAE23639 BC010486 AAH10486 BC037103 XM_006541534 XP_006541597 XM_006541535 XP_006541598 XM_006541536 XP_006541599 NM_026902 NP_081178 |
Function | Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up- regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosph |
Subcellular Location | Cytoplasm {ECO:0000250}. |
MCTS1 CRISPR/Cas9 KO Plasmid (m) - sc-427258 from Santa Cruz Biotechnology
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MCTS1 HDR Plasmid (m) - sc-427258-HDR from Santa Cruz Biotechnology
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MCTS1 Double Nickase Plasmid (m) - sc-427258-NIC from Santa Cruz Biotechnology
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MCTS1 Double Nickase Plasmid (m2) - sc-427258-NIC-2 from Santa Cruz Biotechnology
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MCTS1 CRISPR Activation Plasmid (m) - sc-427258-ACT from Santa Cruz Biotechnology
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MCTS1 CRISPR Activation Plasmid (m2) - sc-427258-ACT-2 from Santa Cruz Biotechnology
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MCTS1 Lentiviral Activation Particles (m) - sc-427258-LAC from Santa Cruz Biotechnology
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MCTS1 Lentiviral Activation Particles (m2) - sc-427258-LAC-2 from Santa Cruz Biotechnology
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MCTS1 siRNA (m) - sc-149331 from Santa Cruz Biotechnology
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MCTS1 shRNA Plasmid (m) - sc-149331-SH from Santa Cruz Biotechnology
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MCTS1 shRNA (m) Lentiviral Particles - sc-149331-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU009911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN35389 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35389 from Sigma-Aldrich
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MCTS1 siRNA (Mouse) - CRM7840 from Cohesion Biosciences
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shRNA set against Mouse MCTS1 (NM_026902.3) - SHH339539 from Creative biogene
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shRNA set against Mouse Mcts1(NM_026902.3) - SHH182189 from Creative biogene
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Mouse MCTS1 siRNA - orb287316 from Biorbyt
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MCTS1 shRNA Plasmid (Mouse) - CHM7840 from Cohesion Biosciences
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MCTS1 miRNA 3'UTR clone - MiUTR1M-07016 from Creative biogene
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