Gene Symbol | VEGFB |
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Entrez Gene | 7423 |
Alt Symbol | VEGFL, VRF |
Species | Human |
Gene Type | protein-coding |
Description | vascular endothelial growth factor B |
Other Description | VEGF-related factor |
Swissprots | Q16528 P49765 |
Accessions | AAA91464 AAD14880 AAL79000 AAL79001 ABY87555 AGC09607 CAI84577 CAL33849 EAW74221 EAW74222 EAW74223 P49765 BC008818 AAH08818 BG031449 BM694361 BU730521 DQ892633 ABM83559 DQ895870 ABM86796 DQ895872 ABM86798 U43368 AAA91462 U43369 AAA91463 U48801 AAB06274 U52819 AAC50721 NM_001243733 NP_001230662 NM_003377 NP_003368 |
Function | Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. |
Subcellular Location | Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin. |
Tissue Specificity | Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. |
Top Pathways | Cytokine-cytokine receptor interaction, Focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway |
VEGF-B CRISPR/Cas9 KO Plasmid (h) - sc-401522 from Santa Cruz Biotechnology
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VEGF-B HDR Plasmid (h) - sc-401522-HDR from Santa Cruz Biotechnology
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VEGF-B Double Nickase Plasmid (h) - sc-401522-NIC from Santa Cruz Biotechnology
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VEGF-B Double Nickase Plasmid (h2) - sc-401522-NIC-2 from Santa Cruz Biotechnology
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VEGF-B CRISPR Activation Plasmid (h) - sc-401522-ACT from Santa Cruz Biotechnology
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VEGF-B CRISPR Activation Plasmid (h2) - sc-401522-ACT-2 from Santa Cruz Biotechnology
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VEGF-B Lentiviral Activation Particles (h) - sc-401522-LAC from Santa Cruz Biotechnology
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VEGF-B Lentiviral Activation Particles (h2) - sc-401522-LAC-2 from Santa Cruz Biotechnology
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VEGF-B siRNA (h) - sc-39840 from Santa Cruz Biotechnology
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VEGF-B shRNA Plasmid (h) - sc-39840-SH from Santa Cruz Biotechnology
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VEGF-B shRNA (h) Lentiviral Particles - sc-39840-V from Santa Cruz Biotechnology
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VEGF-B RNAi - H00007423-R02 from Novus Biologicals
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MISSION® esiRNA - EHU023211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22667 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22667 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03524 from Sigma-Aldrich
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VEGFB siRNA (Human) - CRH5079 from Cohesion Biosciences
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VEGF-B RNAi - H00007423-R01 from Novus Biologicals
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VEGFB - MBS8227645 from MyBioSource
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shRNA set against Human VEGFB (NM_003377.4) - SHH442584 from Creative biogene
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shRNA set against Human VEGFB(NM_003377.4) - SHL125226 from Creative biogene
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VEGFB shRNA Plasmid (Human) - CHH5079 from Cohesion Biosciences
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VEGFB miRNA 3'UTR clone - MiUTR1H-11113 from Creative biogene
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