DLG4

Gene Symbol DLG4
Entrez Gene 1742
Alt Symbol PSD95, SAP-90, SAP90
Species Human
Gene Type protein-coding
Description discs, large homolog 4 (Drosophila)
Other Description Tax interaction protein 15|discs large homolog 4|disks large homolog 4|post-synaptic density protein 95|postsynaptic density protein 95|synapse-associated protein 90
Swissprots G5E939 Q92941 Q9UKK8 B7Z1S1 P78352
Accessions AAD56173 EAW90251 EAW90252 EAW90253 EAW90254 EAW90255 P78352 AA954439 AF028825 AAB84250 AK293835 BAH11607 AK296357 BAH12328 AK297346 BAH12558 AK299801 BAH13133 AK307804 AK308533 AK316096 BAH14467 BC030203 BC040533 AAH40533 BC136553 AAI36554 BC144237 U68138 AAB07736 U83192 AAC52113 XM_005256489 XP_005256546 XM_005256491 XP_005256548 XM_005256492 XP_005256549 XM_005256493 XP_005256550 XM_005256494 XP_005256551 XM_011523698 XP_011522000 XM_011523699 XP_011522001 XM_011523700 XP_011522002 XM_011523701 XP_011522003 XM_011523702 XP_011522004 XR_243545 XR_934005 NM_001128827 NP_001122299 NM_001365 NP_001356
Function Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12151521}; Peripheral membrane protein {ECO:0000269|PubMed:12151521}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269|PubMed:12151521}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Cell junction, synapse {ECO:0000269|PubMed:12151521}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
Tissue Specificity Brain.
Top Pathways Huntington's disease, Glutamatergic synapse, Cocaine addiction, Hippo signaling pathway

Rat DLG4 / PSD95 ELISA Kit (Sandwich ELISA) - LS-F6865 from LifeSpan Bioscience

Category ELISA Kit
Prices $780.00
Sizes 1 plate
Sensitivity 0.113 ng/ml
Range 0.313-20 ng/ml

Mouse DLG4 / PSD95 ELISA Kit (Sandwich ELISA) - LS-F7142 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 0.156 ng/ml
Range 0.313-20 ng/ml

Discs, Large Homolog 4 (DLG4), ELISA Kit - MBS2019180 from MyBioSource

Category ELISA Kit
Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of DLG4 is typically less than 0.113ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration.
Range 0.312-20ng/mL. The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.312ng/mL.

Discs, Large Homolog 4 (DLG4), ELISA Kit - MBS2019506 from MyBioSource

Category ELISA Kit
Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <0.056ng/mL
Range 0.156-10ng/mL

discs, large homolog 4 (Drosophila) , ELISA Kit - MBS9338422 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/ml.
Range 0.25 ng/ml - 8 ng/ml.

ELISA Kit for Discs, Large Homolog 4 (DLG4) - SEG168Mu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Discs, Large Homolog 4 (DLG4) - SEG168Ra from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.113ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Rat DLG4 / PSD95 ELISA Kit (Custom ELISA) - LS-F16580 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.313-20 ng/ml

Human DLG4 / PSD95 ELISA Kit (Custom ELISA) - LS-F16581 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.313-20 ng/ml

Mouse DLG4 / PSD95 ELISA Kit (Custom ELISA) - LS-F16582 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.313-20 ng/ml

Human Disks large homolog 4 ELISA Kit - abx250693 from Abbexa

Category ELISA Kit
Range 0.312 ng/ml - 20 ng/ml

Human Disks large homolog 4 ELISA Kit - EKE53211 from Biomatik

Category ELISA Kit
Prices $685.40, $2,912.95, $5,483.20
Sizes 96 t, 5x96t, 10x96t
Sensitivity The minimum detectable dose of this kit is typically less than 0.097 ng/mL
Range 0.312-20 ng/mL

DLG4 ELISA Kit (Human) : 96 Wells (OKEH02230) - OKEH02230 from Aviva Systems Biology

Category ELISA Kit
Prices $420.00
Sizes 96 wells
Sensitivity < 0.097 ng/mL
Range 0.312 - 20 ng/mL

Human Disks large homolog 4 ELISA Kit - EK3037 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Sensitivity less than 0.097ng/mL
Range 0.312-20 ng/mL

anti-PSD95 antibody [6G6] - ARG20545 from Arigo Biolaboratories

Category ELISA Kit

anti-PSD95 antibody [7E3] - ARG20546 from Arigo Biolaboratories

Category ELISA Kit

anti-PSD95 antibody - ARG55199 from Arigo Biolaboratories

Category ELISA Kit

anti-PSD95 antibody [6G6] (FITC) - ARG20549 from Arigo Biolaboratories

Category ELISA Kit

anti-PSD95 antibody [7E3] (FITC) - ARG20550 from Arigo Biolaboratories

Category ELISA Kit

anti-PSD95 antibody [RM288] - ARG57273 from Arigo Biolaboratories

Category ELISA Kit

anti-PSD95 antibody [6G6] (AP) - ARG20547 from Arigo Biolaboratories

Category ELISA Kit

anti-PSD95 antibody [7E3] (AP) - ARG20548 from Arigo Biolaboratories

Category ELISA Kit

anti-PSD95 antibody [6G6] (RPE) - ARG20551 from Arigo Biolaboratories

Category ELISA Kit

anti-PSD95 antibody [7E3] (RPE) - ARG20552 from Arigo Biolaboratories

Category ELISA Kit

anti-PSD95 antibody - ARG52404 from Arigo Biolaboratories

Category ELISA Kit
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