DLG4

Gene Symbol DLG4
Entrez Gene 1742
Alt Symbol PSD95, SAP-90, SAP90
Species Human
Gene Type protein-coding
Description discs, large homolog 4 (Drosophila)
Other Description Tax interaction protein 15|discs large homolog 4|disks large homolog 4|post-synaptic density protein 95|postsynaptic density protein 95|synapse-associated protein 90
Swissprots G5E939 Q92941 Q9UKK8 B7Z1S1 P78352
Accessions AAD56173 EAW90251 EAW90252 EAW90253 EAW90254 EAW90255 P78352 AA954439 AF028825 AAB84250 AK293835 BAH11607 AK296357 BAH12328 AK297346 BAH12558 AK299801 BAH13133 AK307804 AK308533 AK316096 BAH14467 BC030203 BC040533 AAH40533 BC136553 AAI36554 BC144237 U68138 AAB07736 U83192 AAC52113 XM_005256489 XP_005256546 XM_005256491 XP_005256548 XM_005256492 XP_005256549 XM_005256493 XP_005256550 XM_005256494 XP_005256551 XM_011523698 XP_011522000 XM_011523699 XP_011522001 XM_011523700 XP_011522002 XM_011523701 XP_011522003 XM_011523702 XP_011522004 XR_243545 XR_934005 NM_001128827 NP_001122299 NM_001365 NP_001356
Function Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12151521}; Peripheral membrane protein {ECO:0000269|PubMed:12151521}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269|PubMed:12151521}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Cell junction, synapse {ECO:0000269|PubMed:12151521}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
Tissue Specificity Brain.
Top Pathways Huntington's disease, Glutamatergic synapse, Cocaine addiction, Hippo signaling pathway

PSD-95 CRISPR/Cas9 KO Plasmid (h) - sc-400830 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-95 HDR Plasmid (h) - sc-400830-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-95 Double Nickase Plasmid (h) - sc-400830-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-95 Double Nickase Plasmid (h2) - sc-400830-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-95 CRISPR Activation Plasmid (h) - sc-400830-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-95 CRISPR Activation Plasmid (h2) - sc-400830-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-95 Lentiviral Activation Particles (h) - sc-400830-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-95 Lentiviral Activation Particles (h2) - sc-400830-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-95 siRNA (h) - sc-42010 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PSD-95 shRNA Plasmid (h) - sc-42010-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PSD-95 shRNA (h) Lentiviral Particles - sc-42010-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU071731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0620 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0621 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0622 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN7287 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7287 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DLG4 siRNA (Human) - CRH1210 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DLG4 - MBS8219705 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PSD-95 CRISPR/Cas9 KO Plasmid (h2) - sc-400830-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-95 HDR Plasmid (h2) - sc-400830-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human Dlg4 (NM_001365.3) - SHH278513 from Creative biogene

Category siRNA
Species Reactivities Human

DLG4 shRNA Plasmid (Human) - CHH1210 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DLG4 miRNA 3'UTR clone - MiUTR3H-05383 from Creative biogene

Species Reactivities Human

DLG4 miRNA 3'UTR clone - MiUTR3H-05384 from Creative biogene

Species Reactivities Human
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