| Gene Symbol |
GNAI1
|
| Entrez Gene |
2770
|
| Alt Symbol |
Gi
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
|
| Other Description |
Gi1 protein alpha subunit|adenylate cyclase-inhibiting G alpha protein|guanine nucleotide-binding protein G(i) subunit alpha-1
|
| Swissprots |
Q9UGA4 C9J3A4 P63096 B4E2V1 A8KA88 P11015 P31871 P04898 Q8TAN5 Q5U074
|
| Accessions |
AAA35893 AAC03418 EAW77009 EAW77010 EAW77011 EAW77012 P63096 AF055013 AAC09361 AF493905 AAM12619 AI878901 AK292953 BAF85642 AK304442 BAG65263 AL049933 CAB43212 AM393657 CAL38533 BC026326 AAH26326 BT019775 AAV38580 CD299597 DQ892385 ABM83311 DQ895598 ABM86524 DQ895599 ABM86525 M17219 AAA52581 NM_001256414 NP_001243343 NM_002069 NP_002060
|
| Function |
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. {ECO:0000269|PubMed:17264214, ECO:0000269|PubMed:17635935}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Note=Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. {ECO:0000250}.
|
| Top Pathways |
Circadian entrainment, Oxytocin signaling pathway, Estrogen signaling pathway, Adrenergic signaling in cardiomyocytes, Glutamatergic synapse
|