MDM2

Gene Symbol	MDM2
Entrez Gene	4193
Alt Symbol	ACTFS, HDMX, hdm2
Species	Human
Gene Type	protein-coding
Description	MDM2 proto-oncogene, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase Mdm2|MDM2 oncogene, E3 ubiquitin protein ligase|Mdm2, p53 E3 ubiquitin protein ligase homolog|Mdm2, transformed 3T3 cell double minute 2, p53 binding protein|double minute 2, human homolog of; p53-binding protein|oncoprotein Mdm2
Swissprots	Q13300 Q13299 Q8WYJ2 Q53XW0 Q8WYJ1 Q13297 Q13301 Q13298 Q9UGI3 Q00987 Q13226 A8K2S6 Q9UMT8 Q71TW9 A6NL51
Accessions	AAA82061 AAA82237 AAM78554 CAB64448 CAC22426 CAD57166 CAD57167 CAD57168 EAW97201 EAW97202 EAW97203 EAW97204 EAW97205 EAW97206 EAW97207 EAW97208 EAW97209 EAW97210 EAW97211 EAW97212 EAW97213 EAW97214 Q00987 AA708958 AF092843 AAL40178 AF092844 AAL40179 AF092845 AAL40180 AF201370 AAF42995 AF201371 AF385322 AAL13242 AF385323 AAL13243 AF385324 AAL13244 AF385325 AAL13245 AF385326 AAL13246 AF385327 AAL13247 AJ276888 AJ278975 CAC07809 AJ278976 CAC07810 AJ278977 CAC07811 AJ278978 CAC07812 AJ430612 CAD23251 AJ430613 AJ430614 CAD23252 AJ491698 CAD36959 AJ491699 CAD36960 AJ491700 CAD36961 AJ491701 CAD36962 AJ550516 CAD79455 AJ550517 CAD79456 AJ550518 CAD79457 AJ550519 CAD79458 AJ550520 CAD79459 AK290341 BAF83030 AK312105 BAG35041 AM902641 CAP16703 AM902642 CAP16704 AM902643 CAP16705 AM902644 CAP16706 AM902645 CAP16707 AM902646 CAP16708 AM902647 CAP16709 AM902648 CAP16710 AM902649 CAP16711 AM902650 CAP16712 AM902651 CAP16713 AM902652 CAP16714 AM902653 CAP16715 AM902654 CAP16716 AM902655 CAP16717 AM902656 CAP16718 AM902657 CAP16719 AM902658 CAP16720 AM902659 CAP16721 AM902660 CAP16722 AM902661 CAP16723 AM902662 CAP16724 AM902663 CAP16725 AM902664 CAP16726 AM902665 CAP16727 AM902666 CAP16728 AM902667 CAP16729 AM902668 CAP16730 AM902669 CAP16731 AM902670 CAP16732 AM902671 CAP16733 AM902672 CAP16734 AM902673 CAP16735 AM902674 CAP16736 AM902675 CAP16737 AM902676 CAP16738 AM902677 CAP16739 AM902678 CAP16740 AM902679 CAP16741 AM902680 CAP16742 AM902681 CAP16743 BC006795 BC065505 BC107414 BC148522 AAI48523 BC152384 AAI52385 BC152390 AAI52391 BC153117 AAI53118 BE296905 BE930512 BF208689 BT007258 AAP35922 EU076746 ABT17083 EU076747 ABT17084 EU076748 ABT17085 EU076749 ABT17086 GQ848196 ACX31156 HM213901 HM213902 HM213903 HM213904 HY174841 JX015379 AFM80527 JX015380 AFM80528 JX015381 AFM80529 JX015382 AFM80530 JX015383 AFM80531 JX015384 AFM80532 JX015385 AFM80533 JX015386 AFM80534 JX015387 AFM80535 JX015388 AFM80536 JX015389 AFM80537 JX015390 AFM80538 JX015391 AFM80539 JX015392 AFM80540 M92424 AAA60568 U33199 AAA75514 U33200 AAA75515 U33201 AAA75516 U33202 AAA75517 U33203 AAA75518 Z12020 CAA78055 XM_005268872 XP_005268929 XM_006719399 XP_006719462 XM_006719400 XP_006719463 NM_001145337 NP_001138809 NM_001145339 NP_001138811 NM_001145340 NP_001138812 NM_001278462 NP_001265391 NM_002392 NP_002383 NM_001145336 NM_006878 NM_006879 NM_006880 NM_006881 NM_006882 NM_032739
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. {ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269
Subcellular Location	Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.
Tissue Specificity	Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.
Top Pathways	Epstein-Barr virus infection, Proteoglycans in cancer, PI3K-Akt signaling pathway, MicroRNAs in cancer, Cell cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MDM2 full length protein - ab188727 from Abcam Category Protein Prices $572.00 Sizes 50 µg Source E. coli Species Human

Active human MDM2 full length protein - ab188732 from Abcam Category Protein Prices $682.00 Sizes 50 µg Source E. coli Species Human

Human MDM2 full length protein - ab82080 from Abcam Category Protein Source E. coli Species Human

Human MDM2 peptide - ab99166 from Abcam Category Peptide

Human MDM2 peptide - ab48039 from Abcam Category Peptide Species Human

Human MDM2 protein fragment - ab167941 from Abcam Category Protein Source E. coli Species Human

Human MDM2 protein fragment - ab71353 from Abcam Category Protein Source E. coli Species Human

MDM2 Antibody Blocking Peptide - LS-E1750 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDM2 Antibody Blocking Peptide - LS-E1757 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDM2 Antibody Blocking Peptide - LS-E7400 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDM2 Antibody Blocking Peptide - LS-E7426 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDM2 Antibody Blocking Peptide - LS-E25981 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MDM2/HDM2 Protein - H00004193-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MDM2/HDM2 Protein - H00004193-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MDM2/HDM2 Peptide - P1623 from Novus Biologicals Category Peptide Species Human

MDM2/HDM2 Peptide - P0320 from Novus Biologicals Category Peptide Species Human

MDM2/HDM2 Peptide - P0319 from Novus Biologicals Category Peptide Species Human

Mdm2-Antibody-C-term-Blocking-Peptide - BP1254a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MDM2-Antibody-S166-Blocking-Peptide - BP1253e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Mdm2-Antibody-N-term-Blocking-Peptide - BP1253a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-MDM2T218-Antibody-Blocking-peptide - BP3490a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-MDM2S395-Antibody-Blocking-peptide - BP3579a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Biotinylated-MDM2-S186-Non-phospho-Control-Peptide - SP2041d from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

MDM2-S186-Non-phospho-Control-Peptide - SP2041c from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Biotinylated-MDM2-S166-Non-phospho-Control-Peptide - SP2080d from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

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