LEPR

Gene Symbol	LEPR
Entrez Gene	3953
Alt Symbol	CD295, LEP-R, LEPRD, OB-R, OBR
Species	Human
Gene Type	protein-coding
Description	leptin receptor
Other Description	OB receptor|huB219
Swissprots	Q13592 Q13593 P48357 Q92921 Q92920 Q92919 Q13594
Accessions	AAB09673 AGB14642 CAH25983 P48357 AA813024 AI436180 AK001042 AK290208 BAF82897 AW302522 BC031086 AAH31086 BC035120 BC131779 AAI31780 BC160009 AAI60009 BX475249 U43168 AAA93015 U50748 AAC23650 U52912 AAC50509 U52913 AAC50510 U52914 AAC50511 U66495 AAB07495 U66496 AAB07496 U66497 AAB07497 NM_001003679 NP_001003679 NM_001003680 NP_001003680 NM_001198687 NP_001185616 NM_001198688 NP_001185617 NM_001198689 NP_001185618 NM_002303 NP_002294
Function	Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LEPR ORF clone(NM_002303.5) - CDCR008121 from Creative Biomart Species Human Accession NM_002303.5

Human LEPR ORF Clone(NM_001003679.3) - CDCR338884 from Creative Biomart Species Human Accession NM_001003679.3

Human LEPR ORF Clone(NM_001003679.3) - CDCR338885 from Creative Biomart Species Human Accession NM_001003679.3

Human LEPR ORF Clone(NM_001198688.1) - CDCR358934 from Creative Biomart Species Human Accession NM_001198688.1

Human LEPR ORF Clone(NM_001198688.1) - CDCR358935 from Creative Biomart Species Human Accession NM_001198688.1

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone in cloning vector - HG10322-M from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10322-NM from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10322-CF from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10322-NY from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10322-CH from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10322-CM from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10322-NH from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10322-ACR from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10322-ACG from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10322-M-N from Sino Biological Species Human

Human LEP R transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, HA-tagged - HG10322-M-Y from Sino Biological Species Human Accession NM_002303.3

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10322-UT from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10322-CY from Sino Biological Species Human

Human Leptin Receptor/CD295 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10322-NF from Sino Biological Species Human

Human LEPR ORF Clone(NM_001003679.3) - CDCR338884 from Creative biogene Species Human

Mouse LEPR ORF clone (NM_001198688.1) - CDCL126809 from Creative biogene Species Human

Human LEPR ORF clone (NM_002303.5) - CDCL126811 from Creative biogene Species Human

Human Leptin Receptor gene - orb90910 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human Leptin R (NP_002294) VersaClone cDNA - RDC1867 from R&D Systems Prices $499.00 Sizes 10 µg Species Human

Mouse Leptin R (NP_666258) VersaClone cDNA - RDC2183 from R&D Systems Prices $499.00 Sizes 10 µg Species Mouse

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