LEPR

Gene Symbol LEPR
Entrez Gene 3953
Alt Symbol CD295, LEP-R, LEPRD, OB-R, OBR
Species Human
Gene Type protein-coding
Description leptin receptor
Other Description OB receptor|huB219
Swissprots Q13592 Q13593 P48357 Q92921 Q92920 Q92919 Q13594
Accessions AAB09673 AGB14642 CAH25983 P48357 AA813024 AI436180 AK001042 AK290208 BAF82897 AW302522 BC031086 AAH31086 BC035120 BC131779 AAI31780 BC160009 AAI60009 BX475249 U43168 AAA93015 U50748 AAC23650 U52912 AAC50509 U52913 AAC50510 U52914 AAC50511 U66495 AAB07495 U66496 AAB07496 U66497 AAB07497 NM_001003679 NP_001003679 NM_001003680 NP_001003680 NM_001198687 NP_001185616 NM_001198688 NP_001185617 NM_001198689 NP_001185618 NM_002303 NP_002294
Function Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway

Ob-R CRISPR/Cas9 KO Plasmid (h) - sc-400315 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob-R HDR Plasmid (h) - sc-400315-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob-R Double Nickase Plasmid (h) - sc-400315-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob-R Double Nickase Plasmid (h2) - sc-400315-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob-R CRISPR Activation Plasmid (h) - sc-400315-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob-R CRISPR Activation Plasmid (h2) - sc-400315-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob-R Lentiviral Activation Particles (h) - sc-400315-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob-R Lentiviral Activation Particles (h2) - sc-400315-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob-R siRNA (h) - sc-36115 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ob-R shRNA Plasmid (h) - sc-36115-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ob-R shRNA (h) Lentiviral Particles - sc-36115-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU094411 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU087771 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11648 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11648 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LEPR siRNA (Human) - CRH2676 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Leptin R RNAi - H00003953-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Leptin R RNAi - H00003953-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Ob-R CRISPR/Cas9 KO Plasmid (h2) - sc-400315-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob-R HDR Plasmid (h2) - sc-400315-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human Lepr (NM_002303.5) - SHH329619 from Creative biogene

Category siRNA
Species Reactivities Human

Human LEPR siRNA - orb263178 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LEPR shRNA Plasmid (Human) - CHH2676 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LEPR miRNA 3'UTR clone - MiUTR3H-03798 from Creative biogene

Species Reactivities Human
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