| Gene Symbol | ADSL |
|---|---|
| Entrez Gene | 158 |
| Alt Symbol | AMPS, ASASE, ASL |
| Species | Human |
| Gene Type | protein-coding |
| Description | adenylosuccinate lyase |
| Other Description | adenylosuccinase |
| Swissprots | Q5TI34 B0QY76 P30566 O75495 |
| Accessions | AAC83935 EAW60375 EAW60376 EAW60377 P30566 AF067853 AAC21560 AF067854 AAC21561 AK225042 AK291091 BAF83780 AK293722 BAG57152 AK298187 BAG60458 AK300705 BAG62384 AK308662 BC000253 AAH00253 BC018881 BP298407 CR456368 CAG30254 CU012935 CAK54366 CU013223 CAK54665 DQ893326 ABM84252 DQ896642 ABM87641 KJ534763 AHW56403 KJ535007 AHW56646 KJ535020 AHW56659 KJ535041 AHW56680 KJ535056 AHW56695 S60710 AAC60603 X65867 CAA46696 XM_011529976 XP_011528278 XM_011529977 XP_011528279 XM_011529978 XP_011528280 XM_011529979 XP_011528281 XM_011529980 XP_011528282 XM_011529981 XP_011528283 XM_011529982 XP_011528284 XR_937824 XR_937825 XR_937826 NM_000026 NP_000017 NM_001123378 NP_001116850 |
| Function | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. |
| Tissue Specificity | Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1. |
| Top Pathways | Purine metabolism, Alanine, aspartate and glutamate metabolism |