NOX4

Gene Symbol	NOX4
Entrez Gene	50507
Alt Symbol	KOX, KOX-1, RENOX
Species	Human
Gene Type	protein-coding
Description	NADPH oxidase 4
Other Description	kidney oxidase-1|kidney superoxide-producing NADPH oxidase|renal NAD(P)H-oxidase
Swissprots	Q7Z7G3 Q5K3R6 B7Z520 Q5K3R5 Q9NPH5 Q86V92 Q5K3R8 Q5K3R4 A8K715 E7EMD7
Accessions	EAW59353 EAW59354 EAW59355 Q9NPH5 AB041035 BAA95695 AF254621 AAF68973 AF261943 AAF87572 AJ704725 CAG28807 AJ704726 CAG28808 AJ704727 CAG28809 AJ704728 CAG28810 AJ704729 CAG28811 AK057189 BAG51879 AK291830 BAF84519 AK298323 BAH12756 AK298328 BAH12759 AK298357 BAH12765 AK298376 BAH12771 AK311381 AK311389 AW207163 AY288918 AAP41109 BC040105 AAH40105 BC051371 AAH51371 BP376400 BU730205 DA970477 JF432404 ADZ15621 XM_006718849 XP_006718912 XM_011542857 XP_011541159 XM_011542858 XP_011541160 XM_011542859 XP_011541161 NM_001143836 NP_001137308 NM_001143837 NP_001137309 NM_001291926 NP_001278855 NM_001291927 NP_001278856 NM_001291929 NP_001278858 NM_001300995 NP_001287924 NM_016931 NP_058627 NR_120406
Function	Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000305}. Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus.
Tissue Specificity	Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells. {ECO:0000269|PubMed:11032835, ECO:0000269|PubMed:11376945, ECO:0000269|PubMed:15210697, ECO:0000269|PubMed:16324151}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NOX4 Gene cDNA Clone - orb144474 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-NOX4-cDNA-Clone - DC07322 from Abgent, a WuXi AppTec company Prices $780.30 Sizes 10 µg Species Human Accession BC040105

NOX4 cDNA (ANA10349) - ANA10349 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC040105

NOX4 cDNA (ANA10350) - ANA10350 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC040105

NOX4 - MBS1269330 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC040105

Human NOX4 cDNA clone(NM_001143837.1) - CDFH012687 from Creative Biomart Species Human Accession NM_001143837.1

Human NOX4 cDNA clone(NM_001143836.1) - CDFH012688 from Creative Biomart Species Human Accession NM_001143836.1

Human NOX4 ORF Clone(NM_001143836.1) - CDCR351858 from Creative Biomart Species Human Accession NM_001143836.1

Human NOX4 ORF Clone(NM_001143836.1) - CDCR351859 from Creative Biomart Species Human Accession NM_001143836.1

Human NOX4 ORF Clone(NM_001143837.1) - CDCR351860 from Creative Biomart Species Human Accession NM_001143837.1

Human NOX4 ORF Clone(NM_001143837.1) - CDCR351902 from Creative Biomart Species Human Accession NM_001143837.1

Human NOX4 Gene ORF cDNA clone in cloning vector - HG15189-G from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid, N-His tag - HG15189-NH from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15189-NF from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15189-ACR from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid, C-His tag - HG15189-CH from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15189-CF from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15189-NM from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15189-CM from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15189-CY from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid - HG15189-UT from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15189-ACG from Sino Biological Species Human

Human NOX4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15189-NY from Sino Biological Species Human

Human NOX4 ORF clone (NM_001143836.1) - CDCL139265 from Creative biogene Species Human

Human NOX4 ORF clone (NM_001143837.1) - CDCL139267 from Creative biogene Species Human

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