| Gene Symbol |
Serpine1
|
| Entrez Gene |
18787
|
| Alt Symbol |
PAI-1, PAI1, Planh1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
serine (or cysteine) peptidase inhibitor, clade E, member 1
|
| Other Description |
PAI|Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)|endothelial plasminogen activator inhibitor|nexin, plasminogen activator inhibitor type 1|plasminogen activator inhibitor 1|plasminogen activator inhibitor, type I|serine (or cysteine) proteinase inhibitor, clade E, member 1|serpin E1
|
| Swissprots |
P22777
|
| Accessions |
EDL19286 EDL19287 P22777 AK040662 BC054091 AAH54091 GQ872458 ACX48997 GQ872459 ACX48998 M33960 AAA39887 NM_008871 NP_032897
|
| Function |
Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
p53 signaling pathway, Complement and coagulation cascades, Chagas disease (American trypanosomiasis), Hippo signaling pathway
|