FZD2

Gene Symbol	FZD2
Entrez Gene	2535
Alt Symbol	Fz2, fz-2, fzE2, hFz2
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 2
Other Description	frizzled 2, seven transmembrane spanning receptor|frizzled family receptor 2|frizzled homolog 2|frizzled-2
Swissprots	Q14332 Q0VG82
Accessions	EAW51591 Q14332 AB017364 BAA34667 AI376463 AW023425 BC052266 AAH52266 BC113402 AAI13403 BC113404 AAI13405 CN417837 L37882 AAB46397 NM_001466 NP_001457
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular Location	Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity	Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Frizzled 2 protein fragment - ab114412 from Abcam Category Protein Source Wheat germ Species Human

Human Frizzled 2 protein fragment - ab191625 from Abcam Category Protein Source HEK 293 cells Species Human

Frizzled-2 Partial Recombinant Protein - H00002535-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

FZD2-Antibody-C-term-Blocking-Peptide - BP14806b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Frizzled 2 blocking peptide - GTX88690-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

FZD2 Blocking Peptide - 33R-6374 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Frizzled 2 Peptide - AC21-1462-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FZD2 / Frizzled-2 - H00002535-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FZD2 / Frizzled-2 - H00002535-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Frizzled 2 Peptide - 46-844P from ProSci Category Peptide Species Human

Frizzled 2 Recombinant Protein - 96-332 from ProSci Category Protein Prices $425.00 Sizes 100 µg Source HEK293 cells Species Human

FZD2 fusion protein - Ag18003 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

FZD2 fusion protein - Ag19055 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human FZD2 - FZD2-26287TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human FZD2, GST-tagged - FZD2-13065H from Creative Biomart Category Protein Source E.coli Species Human

Frizzled-2 (E240) Peptide - BS3163P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Human Frizzled-2 / FZD2 Protein, Fc Tag - FZ2-H5251 from ACROBiosystems Category Protein Prices $290.00 Sizes 100 µg Source Human Frizzled-2, Fc Tag (FZ2-H5251) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Ser 156 (Accession # AAI13403). Species Human

Frizzled 2, Peptide - MBS426257 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

Recombinant Human FZD2, Fc-tagged - FZD2-135H from Creative Biomart Category Protein Source HEK293 Species Human

Frizzled-2 Recombinant Protein Antigen - NBP2-33842PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Human Frizzled-2 protein - orb257487 from Biorbyt Category Protein Prices $680.00 Sizes 100 μg Species Human

FZD2 Peptide, Human - M34GP05987H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human CellExp™ Frizzled-2 / FZD2 Protein, Human recombinant - P1026-10 from Biovision Category Protein Prices $95.00 Sizes 10 μg Source HEK 293 cells Species Human

Human CellExp™ Frizzled-2 / FZD2 Protein, Human recombinant - P1026-50 from Biovision Category Protein Prices $355.00 Sizes 50 µg Source HEK 293 cells Species Human

Frizzled-2 (FZD2), Recombinant Protein - MBS7015397 from MyBioSource Category Protein Prices $1,340.00, $2,325.00, $3,530.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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