FZD2
| Gene Symbol | FZD2 |
|---|---|
| Entrez Gene | 2535 |
| Alt Symbol | Fz2, fz-2, fzE2, hFz2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 2 |
| Other Description | frizzled 2, seven transmembrane spanning receptor|frizzled family receptor 2|frizzled homolog 2|frizzled-2 |
| Swissprots | Q14332 Q0VG82 |
| Accessions | EAW51591 Q14332 AB017364 BAA34667 AI376463 AW023425 BC052266 AAH52266 BC113402 AAI13403 BC113404 AAI13405 CN417837 L37882 AAB46397 NM_001466 NP_001457 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Subcellular Location | Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
frizzled-2 CRISPR/Cas9 KO Plasmid (h) - sc-401592 from Santa Cruz Biotechnology
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frizzled-2 HDR Plasmid (h) - sc-401592-HDR from Santa Cruz Biotechnology
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frizzled Double Nickase Plasmid (h) - sc-401592-NIC from Santa Cruz Biotechnology
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frizzled-2 Double Nickase Plasmid (h2) - sc-401592-NIC-2 from Santa Cruz Biotechnology
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frizzled CRISPR Activation Plasmid (h) - sc-401592-ACT from Santa Cruz Biotechnology
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frizzled-2 CRISPR Activation Plasmid (h2) - sc-401592-ACT-2 from Santa Cruz Biotechnology
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frizzled Lentiviral Activation Particles (h) - sc-401592-LAC from Santa Cruz Biotechnology
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frizzled-2 Lentiviral Activation Particles (h2) - sc-401592-LAC-2 from Santa Cruz Biotechnology
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frizzled-2 siRNA (h) - sc-39979 from Santa Cruz Biotechnology
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frizzled-2 shRNA Plasmid (h) - sc-39979-SH from Santa Cruz Biotechnology
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frizzled-2 shRNA (h) Lentiviral Particles - sc-39979-V from Santa Cruz Biotechnology
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Frizzled-2 RNAi - H00002535-R02 from Novus Biologicals
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MISSION® esiRNA - EHU136041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9024 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9024 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01126 from Sigma-Aldrich
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FZD2 siRNA (Human) - CRH1680 from Cohesion Biosciences
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FZD2 - MBS8231301 from MyBioSource
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shRNA set against Human FZD2 (NM_001466.3) - SHH298073 from Creative biogene
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Human FZD2 siRNA - orb262182 from Biorbyt
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FZD2 shRNA Plasmid (Human) - CHH1680 from Cohesion Biosciences
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FZD2 miRNA 3'UTR clone - MiUTR3H-03547 from Creative biogene
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