| Gene Symbol |
SPAM1
|
| Entrez Gene |
6677
|
| Alt Symbol |
HEL-S-96n, HYA1, HYAL1, HYAL3, HYAL5, PH-20, PH20, SPAG15
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
|
| Other Description |
epididymis secretory sperm binding protein Li 96n|hyal-PH20|hyaluronidase PH-20|hyaluronoglucosaminidase PH-20|sperm surface protein PH-20
|
| Swissprots |
P38567 Q8TC30
|
| Accessions |
AAQ96882 CBH19453 CBL54474 CBL86562 CCA64576 CCD32726 CCF70987 EAL24329 EAL24330 EAW83604 EAW83605 EAW83606 P38567 AK292229 BAF84918 AY920278 AAX13985 AY920279 AAX13986 AY920280 AAX13987 AY920281 AAX13988 BC026163 AAH26163 BI831525 DB023094 DQ891657 ABM82583 DQ894844 ABM85770 EU794686 ACJ13740 L13779 L13781 S67798 AAC60607 X84347 CAA59086 XM_011516523 XP_011514825 XM_011516524 XP_011514826 XM_011516525 XP_011514827 XM_011516526 XP_011514828 NM_001174044 NP_001167515 NM_001174045 NP_001167516 NM_001174046 NP_001167517 NM_003117 NP_003108 NM_153189 NP_694859
|
| Function |
Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. {ECO:0000269|PubMed:8282124}.
|
| Subcellular Location |
Cell membrane; Lipid-anchor, GPI-anchor.
|
| Tissue Specificity |
Testis. {ECO:0000269|PubMed:8234258}.
|
| Top Pathways |
Glycosaminoglycan degradation
|
![Western Blot: SPAM1 Overexpression Lysate (Adult Normal) [NBL1-16369] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPAM1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/18438_SPAM1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-16369-img0002.jpg)