LNPEP

Gene Symbol	LNPEP
Entrez Gene	4012
Alt Symbol	CAP, IRAP, P-LAP, PLAP
Species	Human
Gene Type	protein-coding
Description	leucyl/cystinyl aminopeptidase
Other Description	AT (4) receptor|angiotensin IV receptor|cystinyl aminopeptidase|insulin-regulated aminopeptidase|insulin-regulated membrane aminopeptidase|insulin-responsive aminopeptidase|leucyl-cystinyl aminopeptidase|otase|oxytocinase|placental leucine aminopeptidase|vasopressinase
Swissprots	Q9TNQ3 Q9UIQ6 Q59H76 Q15145 Q9TNQ2 Q9UIQ7 O00769
Accessions	CAB61646 CAB94753 EAW96084 Q9UIQ6 AB208883 BAD92120 AK096804 AK314226 BAG36898 BC028692 BC111718 BC113117 BC160010 AAI60010 BG622952 BQ923659 D50810 BAA09436 U62768 AAB66672 U62769 AAB66673 NM_005575 NP_005566 NM_175920 NP_787116
Function	Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269|PubMed:11389728}. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
Tissue Specificity	Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:8550619, ECO:0000269|PubMed:9177475}.
Top Pathways	Renin-angiotensin system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Leucyl-cystinyl aminopeptidase protein fragment - ab158825 from Abcam Category Protein Source Wheat germ Species Human

LNPEP Antibody Blocking Peptide - LS-E145 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LNPEP Antibody Blocking Peptide - LS-E31343 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Leucyl-cystinyl Aminopeptidase/LNPEP Partial Recombinant Protein - H00004012-Q01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Leucyl-cystinyl Aminopeptidase/LNPEP Recombinant Protein - P3810 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

LNPEP-Antibody-N-Term-Blocking-peptide - BP10272a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IL1RA protein - 30R-2352 from Fitzgerald Category Protein Prices $135.00, $275.00 Sizes 20 µg, 100 µg Source E.coli Species Human

LNPEP - H00004012-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

LNPEP - P3810 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

LNPEP (C-term) Control Peptide - AP55467CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

LNPEP Peptide - 7055P from ProSci Category Peptide Species Human

IL 1RA Human - CYPS-210 from NeoScientific Category Protein Prices $65.00, $169.00, $1,287.00 Sizes 20 µg, 100 µg, 1 mg Source Escherichia Coli. Species Human

IL 1RA Human His - CYPS-488 from NeoScientific Category Protein Prices $195.00, $650.00, $3,094.00 Sizes 10 µg, 50 µg, 1 mg Source Escherichia Coli. Species Human

IL 1RA Human - BCA-307 from Reagent Proteins Category Protein Prices $348.00, $1,186.00 Sizes 100.00 µg, 1 mg Source E.coli Species Human

IL 1RA Human His - BCA-945 from Reagent Proteins Category Protein Prices $370.00, $726.00, $3,557.00 Sizes 10.00 µg, 50.00 µg, 1 mg Source E.coli Species Human

Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) - RPH723Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human Leucyl-cystinyl aminopeptidase(LNPEP) ,partial - CSB-YP883442HU CSB-EP883442HU CSB-BP883442HU CSB-MP883442HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

IL-1R antagonist Protein (Active) - BRP1038 from Biospes Category Protein Prices $160.00 Sizes 100 μg Source E. Coli Species Human

Interleukin-1 receptor antagonist, IL-1RA Protein (Active) - BRP1039 from Biospes Category Protein Prices $1,000.00 Sizes 1 mg Source E. Coli Species Human

LNPEP (transcript variant 1) - TP320692 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Interleukin-1 Receptor Antagonist Human Recombinant - Pr21266 from ProMab Category Protein Prices $50.00, $130.00, $990.00 Sizes 20 μg, 100 μg, 1 mg Source Escherichia Coli. Species Human

Interleukin-1 Receptor Antagonist Human Recombinant, His Tag - Pr21267 from ProMab Category Protein Prices $150.00, $500.00, $2,380.00 Sizes 10 μg, 50 μg, 1 mg Source Escherichia Coli. Species Human

Leucyl-cystinyl Aminopeptidase/LNPEP Recombinant Protein Antigen - NBP1-92071PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

LNPEP Peptide, Human - M34GP08783H from Creative Peptides Category Peptide Source Synthetic. Species Human

Leucyl-cystinyl aminopeptidase (LNPEP), partial, Recombinant Protein - MBS1360634 from MyBioSource Category Protein Prices $1,195.00, $1,195.00, $1,415.00, $1,415.00, $1,895.00, $1,895.00, $2,355.00, $2,355.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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