LNPEP
| Gene Symbol | LNPEP |
|---|---|
| Entrez Gene | 4012 |
| Alt Symbol | CAP, IRAP, P-LAP, PLAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | leucyl/cystinyl aminopeptidase |
| Other Description | AT (4) receptor|angiotensin IV receptor|cystinyl aminopeptidase|insulin-regulated aminopeptidase|insulin-regulated membrane aminopeptidase|insulin-responsive aminopeptidase|leucyl-cystinyl aminopeptidase|otase|oxytocinase|placental leucine aminopeptidase|vasopressinase |
| Swissprots | Q9TNQ3 Q9UIQ6 Q59H76 Q15145 Q9TNQ2 Q9UIQ7 O00769 |
| Accessions | CAB61646 CAB94753 EAW96084 Q9UIQ6 AB208883 BAD92120 AK096804 AK314226 BAG36898 BC028692 BC111718 BC113117 BC160010 AAI60010 BG622952 BQ923659 D50810 BAA09436 U62768 AAB66672 U62769 AAB66673 NM_005575 NP_005566 NM_175920 NP_787116 |
| Function | Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269|PubMed:11389728}. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases. |
| Tissue Specificity | Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:8550619, ECO:0000269|PubMed:9177475}. |
| Top Pathways | Renin-angiotensin system |
IRAP CRISPR/Cas9 KO Plasmid (h) - sc-403731 from Santa Cruz Biotechnology
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IRAP HDR Plasmid (h) - sc-403731-HDR from Santa Cruz Biotechnology
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IRAP Double Nickase Plasmid (h) - sc-403731-NIC from Santa Cruz Biotechnology
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IRAP Double Nickase Plasmid (h2) - sc-403731-NIC-2 from Santa Cruz Biotechnology
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IRAP CRISPR Activation Plasmid (h) - sc-403731-ACT from Santa Cruz Biotechnology
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IRAP CRISPR Activation Plasmid (h2) - sc-403731-ACT-2 from Santa Cruz Biotechnology
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IRAP Lentiviral Activation Particles (h) - sc-403731-LAC from Santa Cruz Biotechnology
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IRAP Lentiviral Activation Particles (h2) - sc-403731-LAC-2 from Santa Cruz Biotechnology
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IRAP siRNA (h) - sc-91674 from Santa Cruz Biotechnology
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IRAP shRNA Plasmid (h) - sc-91674-SH from Santa Cruz Biotechnology
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IRAP shRNA (h) Lentiviral Particles - sc-91674-V from Santa Cruz Biotechnology
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Leucyl-cystinyl Aminopeptidase/LNPEP RNAi - H00004012-R02 from Novus Biologicals
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MISSION® esiRNA - EHU137201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11786 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11786 from Sigma-Aldrich
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LNPEP siRNA (Human) - CRH2716 from Cohesion Biosciences
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Leucyl-cystinyl Aminopeptidase/LNPEP RNAi - H00004012-R01 from Novus Biologicals
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shRNA set against Human Lnp (NM_005575.2) - SHH331171 from Creative biogene
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shRNA set against Human LNPEP(NM_005575.2) - SHH152705 from Creative biogene
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shRNA set against Human LNPEP(NM_175920.3) - SHH152759 from Creative biogene
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Human LNPEP siRNA - orb263218 from Biorbyt
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LNPEP shRNA Plasmid (Human) - CHH2716 from Cohesion Biosciences
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LNPEP miRNA 3'UTR clone - MiUTR1H-05717 from Creative biogene
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LNPEP miRNA 3'UTR clone - MiUTR1H-05718 from Creative biogene
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