| Gene Symbol |
GLS
|
| Entrez Gene |
2744
|
| Alt Symbol |
AAD20, GAC, GAM, GLS1, KGA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutaminase
|
| Other Description |
K-glutaminase|L-glutamine amidohydrolase|glutaminase C|glutaminase kidney isoform, mitochondrial|glutaminase, phosphate-activated
|
| Swissprots |
Q9UL07 Q9UL05 Q9UL06 O94925 Q9UN40
|
| Accessions |
AAY14767 AAY24182 AAY24320 EAX10856 EAX10857 EAX10858 EAX10859 EAX10860 O94925 AB020645 BAA74861 AF097492 AAF00088 AF097493 AAF00089 AF097494 AF097495 AAF00090 AF158555 AAD47056 AF223943 AAF33825 AF279697 AAG17700 AF327434 AAG47842 AJ431620 AK001220 BAG50870 AK092974 AK123493 AK289747 BAF82436 AK294927 BAH11927 AK298266 BAH12745 BC038507 AAH38507 BM148085 BX641148 CR749593 CAH18392 Y08264 XM_005246467 XP_005246524 XM_006712435 XP_006712498 XR_241306 XR_922905 NM_001256310 NP_001243239 NM_014905 NP_055720
|
| Function |
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.
|
| Subcellular Location |
Isoform 1: Cytoplasm, cytosol.
|
| Tissue Specificity |
Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle. {ECO:0000269|PubMed:11015561}.
|
| Top Pathways |
Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation
|
![Western Blot: Glutaminase Overexpression Lysate (Adult Normal) [NBP2-10302] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Glutaminase.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2268_Glutaminase%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10302-img0001.jpg)