GLS

Gene Symbol GLS
Entrez Gene 2744
Alt Symbol AAD20, GAC, GAM, GLS1, KGA
Species Human
Gene Type protein-coding
Description glutaminase
Other Description K-glutaminase|L-glutamine amidohydrolase|glutaminase C|glutaminase kidney isoform, mitochondrial|glutaminase, phosphate-activated
Swissprots Q9UL07 Q9UL05 Q9UL06 O94925 Q9UN40
Accessions AAY14767 AAY24182 AAY24320 EAX10856 EAX10857 EAX10858 EAX10859 EAX10860 O94925 AB020645 BAA74861 AF097492 AAF00088 AF097493 AAF00089 AF097494 AF097495 AAF00090 AF158555 AAD47056 AF223943 AAF33825 AF279697 AAG17700 AF327434 AAG47842 AJ431620 AK001220 BAG50870 AK092974 AK123493 AK289747 BAF82436 AK294927 BAH11927 AK298266 BAH12745 BC038507 AAH38507 BM148085 BX641148 CR749593 CAH18392 Y08264 XM_005246467 XP_005246524 XM_006712435 XP_006712498 XR_241306 XR_922905 NM_001256310 NP_001243239 NM_014905 NP_055720
Function Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.
Subcellular Location Isoform 1: Cytoplasm, cytosol.
Tissue Specificity Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle. {ECO:0000269|PubMed:11015561}.
Top Pathways Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation

KGA CRISPR/Cas9 KO Plasmid (h) - sc-402575 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KGA HDR Plasmid (h) - sc-402575-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KGA Double Nickase Plasmid (h) - sc-402575-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KGA Double Nickase Plasmid (h2) - sc-402575-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KGA CRISPR Activation Plasmid (h) - sc-402575-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KGA CRISPR Activation Plasmid (h2) - sc-402575-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KGA Lentiviral Activation Particles (h) - sc-402575-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KGA Lentiviral Activation Particles (h2) - sc-402575-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KGA siRNA (h) - sc-105592 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KGA shRNA Plasmid (h) - sc-105592-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KGA shRNA (h) Lentiviral Particles - sc-105592-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU085901 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9361 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9361 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12827 from Sigma-Aldrich

Category miRNA

GLS siRNA (Human) - CRH1828 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GLS - MBS8206049 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GLS (NM_014905.4) - SHH302038 from Creative biogene

Category siRNA
Species Reactivities Human

GLS shRNA Plasmid (Human) - CHH1828 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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