Il1a

Gene Symbol	Il1a
Entrez Gene	16175
Alt Symbol	Il-1a
Species	Mouse
Gene Type	protein-coding
Description	interleukin 1 alpha
Other Description	IL-1 alpha\|interleukin-1 alpha
Swissprots	P01582
Accessions	AAC28999 AAX90603 EDL28236 EDL28237 P01582 AK156449 BAE33715 BC003727 AAH03727 M14639 AAA40058 X01450 CAA25682 XM_006498793 XP_006498856 XM_006498794 XP_006498857 NM_010554 NP_034684
Function	Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Subcellular Location	Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Top Pathways	Apoptosis, Inflammatory bowel disease (IBD), Non-alcoholic fatty liver disease (NAFLD), Hematopoietic cell lineage, Graft-versus-host disease

IL-1α (C-18) - sc-1253 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

IL-1α (C-18): sc-1253. Western blot analysis of human (A) and mouse (B) recombinant IL-1α.

IL-1α (M-20) - sc-1279 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

IL-1α (M-20): sc-1279. Western blot analysis of human (A) and mouse (B) recombinant IL-1α.

IL-1α (R-20) - sc-1254 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

IL-1α (R-20): sc-1254. Western blot analysis of human (A) and mouse (B) recombinant IL-1α.

Anti-IL1 alpha antibody - ab9724 from Abcam

Prices	$379.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Staining of colchicine injected mouse brain (including the hippocampal fissure) tissue. The primary antibody was incubated at 1.0 ug/ml overnight at 4°C. This was followed by a peroxidase conjugated secondary antibody and then a fluorescein reagent. Optimal concentrations and conditions may vary.

Anti-IL1 alpha antibody - ab109555 from Abcam

Prices	$379.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

ab109555 stained Raw 246.7 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab109555 at 10µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-IL1 alpha antibody [ALF-161] - Low endotoxin, Azide free - ab185750 from Abcam

Prices	$368.00
Sizes	50 µg
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody [Unconjugated] - AF-400-NA from Novus Biologicals

Prices	$99.00, $365.00
Sizes	25 µg, 100 µg
Host	Goat
Clonality	Polyclonal

Recombinant Mouse IL‑1 alpha /IL‑1F1 (Catalog # 400-ML) stimulates proliferation in the the D10.G4.1 mouse helper T cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL‑1 alpha /IL‑1F1 (50 pg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse IL‑1 alpha /IL‑1F1 Antigen Affinity‑purified Polyclonal Antibody (Catalog # AF-400-NA). The ND50 is typically 0.002-0.004 µg/mL in the presence of concanavalin A (1.25 µg/mL).

IL-1 alpha/IL-1F1 Antibody (40508) [Unconjugated] - MAB400 from Novus Biologicals

Prices	$99.00, $269.00, $699.00
Sizes	25 µg, 100 µg, 500 µg
Host	Rat
Clonality	Monoclonal
Clone	40508

IL-1 alpha/IL-1F1 Antibody - AB-400-NA from Novus Biologicals

Prices	$359.00
Sizes	1 mg
Host	Goat
Clonality	Polyclonal

IL-1 alpha/IL-1F1 Antibody (ALF-161) - NBP1-43247 from Novus Biologicals

Prices	$249.00, $369.00
Sizes	50 µg, 500 µg
Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

Flow Cytometry: IL-1 alpha/IL-1F1 Antibody (ALF-161) [NBP1-43247] - Analysis using the FITC conjugate of NBP1-43247. Mouse thiogylcolate-induced peritoneal exudate cells (PECs) were stimulated with LPS in the presence of Brefeldin A for 22 hours. The cells were surface stained with Anti-Mouse CD11b PE and then intracellularly stained with Rat IgG2b kappa Isotype Control FITC (left) or Anti-Mouse IL-1 alpha FITC (right).

IL-1 alpha/IL-1F1 Antibody [Biotin] - BAF400 from Novus Biologicals

Prices	$420.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

IL-1 alpha/IL-1F1 Antibody (ALF-161) [PE] - NBP1-43247PE from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [DyLight 350] - NBP1-43247UV from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [7C] - NBP1-43247V2 from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [DyLight 405] - NBP1-43247V from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [PerCP] - NBP1-43247PCP from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [Allophycocyanin] - NBP1-43247APC from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [DyLight 488] - NBP1-43247G from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [DyLight 405LS] - NBP1-43247V3 from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [DyLight 755] - NBP1-43247IR from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [DyLight 680] - NBP1-43247FR from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [FITC] - NBP1-43931 from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

Flow Cytometry: IL1 alpha Antibody (ALF-161) [FITC] [NBP1-43931] - Mouse thiogylcolate-induced peritoneal exudate cells (PECs) were stimulated with LPS in the presence of Brefeldin A for 22 hours. The cells were surface stained with Anti-Mouse CD11b PE and then intracellularly stained with Rat IgG2b kappa Isotype Control FITC (left) or Anti-Mouse IL-1 alpha FITC (right).

IL-1 alpha/IL-1F1 Antibody [Biotin] - NBP2-00392 from Novus Biologicals

Host	Rabbit
Clonality	Polyclonal

IL-1 alpha/IL-1F1 Antibody (ALF-161) [Alexa Fluor (R) 700] - NBP1-43247AF700 from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

IL-1 alpha/IL-1F1 Antibody (ALF-161) [Alexa Fluor (R) 647] - NBP1-43247AF647 from Novus Biologicals

Host	Hamster
Clonality	Monoclonal
Clone	ALF-161

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