| Gene Symbol | Il1a |
|---|---|
| Entrez Gene | 16175 |
| Alt Symbol | Il-1a |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | interleukin 1 alpha |
| Other Description | IL-1 alpha|interleukin-1 alpha |
| Swissprots | P01582 |
| Accessions | AAC28999 AAX90603 EDL28236 EDL28237 P01582 AK156449 BAE33715 BC003727 AAH03727 M14639 AAA40058 X01450 CAA25682 XM_006498793 XP_006498856 XM_006498794 XP_006498857 NM_010554 NP_034684 |
| Function | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
| Subcellular Location | Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. |
| Top Pathways | Apoptosis, Inflammatory bowel disease (IBD), Non-alcoholic fatty liver disease (NAFLD), Hematopoietic cell lineage, Graft-versus-host disease |