| Gene Symbol |
AATF
|
| Entrez Gene |
26574
|
| Alt Symbol |
BFR2, CHE-1, CHE1, DED
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apoptosis antagonizing transcription factor
|
| Other Description |
apoptosis-antagonizing transcription factor|protein AATF|rb-binding protein Che-1
|
| Swissprots |
Q9P0A4 A6NCJ6 B3KQ26 Q9NY61 Q9UNX5
|
| Accessions |
EAW57575 Q9NY61 AF083208 AAD52016 AF161395 AAF28955 AJ249940 CAB57451 AK026173 AK057229 BAG51888 AK130740 BC000591 AAH00591 DQ892097 ABM83023 DQ895290 ABM86216 XM_011524611 XP_011522913 XM_011546799 XP_011545101 XR_934439 XR_951958 NM_012138 NP_036270
|
| Function |
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
|
| Tissue Specificity |
Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus. {ECO:0000269|PubMed:10783144, ECO:0000269|PubMed:11027528}.
|