AATF

Gene Symbol	AATF
Entrez Gene	26574
Alt Symbol	BFR2, CHE-1, CHE1, DED
Species	Human
Gene Type	protein-coding
Description	apoptosis antagonizing transcription factor
Other Description	apoptosis-antagonizing transcription factor|protein AATF|rb-binding protein Che-1
Swissprots	Q9P0A4 A6NCJ6 B3KQ26 Q9NY61 Q9UNX5
Accessions	EAW57575 Q9NY61 AF083208 AAD52016 AF161395 AAF28955 AJ249940 CAB57451 AK026173 AK057229 BAG51888 AK130740 BC000591 AAH00591 DQ892097 ABM83023 DQ895290 ABM86216 XM_011524611 XP_011522913 XM_011546799 XP_011545101 XR_934439 XR_951958 NM_012138 NP_036270
Function	May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272}.
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Tissue Specificity	Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus. {ECO:0000269|PubMed:10783144, ECO:0000269|PubMed:11027528}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AATF full length protein - ab162011 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human AATF peptide - ab41847 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Human AATF protein fragment - ab162012 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

AATF Antibody Blocking Peptide - LS-E11115 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AATF Antibody Blocking Peptide - LS-E14040 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AATF Antibody Blocking Peptide - LS-E14041 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AATF Antibody Blocking Peptide - LS-E29999 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human AATF Protein - H00026574-P01 from Novus Biologicals Category Protein Prices $275.00 Sizes 2 µg Source Wheat Germ Species Human

AATF Partial Recombinant Protein - H00026574-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

AATF Blocking Peptide - NBP1-76655PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant human protein AATF (OPCA00580) - OPCA00580 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human AATF CHE1 protein - orb245238 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

AATF Blocking Peptide - abx063808 from Abbexa Category Peptide Species Human, Monkey

AATF - H00026574-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

AATF - H00026574-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

AATF - H00026574-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

AATF - H00026574-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AATF - H00026574-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AATF Control Peptide - AP30004CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

AATF Peptide - 3039P from ProSci Category Peptide Species Human

AATF fusion protein - Ag0195 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Recombinant Human AATF, GST-tagged - AATF-9201H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Apoptosis Antagonizing Transcription Factor (AATF) - RPA440Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Apoptosis Antagonizing Transcription Factor (AATF) - RPA440Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Apoptosis Antagonizing Transcription Factor (AATF) - RPA440Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

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