MAPK13

Gene Symbol MAPK13
Entrez Gene 5603
Alt Symbol MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase 13
Other Description MAP kinase 13|MAP kinase p38 delta|mitogen-activated protein kinase p38 delta|stress-activated protein kinase 4
Swissprots Q5U4A5 Q9UNU0 Q6FI46 O15264 O15124 O14739
Accessions EAX03874 EAX03875 EAX03876 O15264 AB209586 BAD92823 AB451221 BAG70035 AB451344 BAG70158 AF004709 AAC51374 AF015256 AAC51758 AF092535 AAD23377 AF100546 AAF36772 AK222922 BAD96642 AK308018 BC000433 AAH00433 BC001641 AAH01641 BC004428 AAH04428 BC085196 AAH85196 BM921729 BT007221 AAP35885 CR536490 CAG38729 CR541687 CAG46488 DB335275 DB473379 DQ588728 DQ891372 ABM82298 DQ894551 ABM85477 DR006449 EU832156 ACE87506 EU832250 ACE86820 U93232 AAB87639 Y10488 CAA71512 NM_002754 NP_002745 NR_072996
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an importan
Tissue Specificity Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells. {ECO:0000269|PubMed:10201954, ECO:0000269|PubMed:9374491}.
Top Pathways VEGF signaling pathway, Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Retrograde endocannabinoid signaling, Proteoglycans in cancer

p38δ MAPK Antibody - 9214 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HEK293, THP1 and Ramos cells, using p38δ MAPK Antibody.

p38δ MAPK (10A8) Rabbit mAb - 2308 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 10A8
Western blot analysis of purified recombinant full-length p38 MAPK GST fusion proteins, using p38 MAPK pan antibody (upper), or p38δ MAPK (10A8) Rabbit mAb (lower).

SAPK4 (D-2) - sc-376437 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAPK4 (D-2): sc-376437. Western blot analysis of SAPK4 expression in non-transfected: sc-117752 (A) and mouse SAPK4 transfected: sc-123351 (B) 293T whole cell lysates.

SAPK4 (E-3) - sc-271292 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAPK4 (E-3): sc-271292. Western blot analysis of SAPK4 expression in non-transfected: sc-117752 (A) and mouse SAPK4 transfected: sc-123351 (B) 293T whole cell lysates.

SAPK4 (E-7) - sc-46678 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAPK4 (E-7): sc-46678. Western blot analysis of SAPK4 expression in A-431 whole cell lysate.

SAPK4 (GST-D1) - sc-33691 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAPK4 (GST-D1): sc-33691. Western blot analysis of human recombinant SAPK4.

SAPK4 (C-19) - sc-7585 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SAPK4 (C-19): sc-7585. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human pancreas tumor showing cytoplasmic staining.

SAPK4 (N-17) - sc-7587 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SAPK4 (N-17): sc-7587. Immunofluorescence staining of methanol-fixed A-431 cells showing cytoplasmic staining.

SAPK4 (H-60) - sc-20706 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of SAPK4 expression in A-431 whole cell lysate (A,B). Antibodies tested include SAPK4 (N-17): sc-7587 (A) and SAPK4 (H-60): sc-20706 (B).

SAPK4 (20) - sc-136063 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
SAPK4 (20): sc-136063. Western blot analysis of SAPK4 expression in A-431 whole cell lysate.

Anti-SAPK4 antibody - ab37936 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SAPK4 antibody (ab37936) at 1/100 dilutionLane 1 : nocodazole treated HCT116 cell lysateLane 2 : PMA-treated Pam212 cell lysate

Anti-SAPK4 antibody - ab199149 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling SAPK4 with ab199149 at 1/15 dilution.

Anti-SAPK4 antibody - ab57718 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
SAPK4 antibody (ab57718) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human testis.

Anti-SAPK4 antibody - ab57719 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
SAPK4 antibody (ab57719) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human small Intestine.

Anti-SAPK4 antibody [2D8] - ab117565 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2D8
ab117565, at 5 µg/ml, staining SAPK4 in formalin fixed, paraffin embedded Human prostate tissue by Immunohistochemistry.

Anti-SAPK4 antibody [EPR14611] - ab188324 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14611
All lanes : Anti-SAPK4 antibody [EPR14611] (ab188324) at 1/1000 dilutionLane 1 : THP-1 cell lysateLane 2 : 293 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-SAPK4 antibody [I14-L] - C-terminal - ab183203 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone I14-L
Immunofluorescent analysys of HEK293 cells labeling SAPK4 with ab183203 at 1/300 dilution.

Anti-SAPK4 antibody - C-terminal - ab200120 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-SAPK4 antibody - C-terminal (ab200120) at 1/1000 dilutionLane 1 : Total cell extracts from mouse thymusLane 2 : Total cell extracts from HeLa cells

Anti-MAPK13 / p38delta Antibody (aa353-365) - LS-C17763 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPK13 / p38delta Antibody (aa215-264) - LS-C116636 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MAPK13 / SAPK4 antibody LS-C116636 Western blot of Jurkat lysate.

Anti-MAPK13 / p38delta Antibody (N-Terminus, Magnetic beads) - LS-C171773 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPK13 / p38delta Antibody (N-Terminus, Sepharose) - LS-C171774 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPK13 / p38delta Antibody - LS-C155329 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: HepG2 10% SDS PAGE MAPK13 / SAPK4 antibody diluted at 1:1000

Anti-MAPK13 / p38delta Antibody (aa353-365) - LS-C152755 from LifeSpan Bioscience

Prices $355.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
WB: 1-4g/ml of this lot detected p38/SAPK4 in RIPA lysates from C6 rat glioma cells

Anti-MAPK13 / p38delta Antibody (aa336-364) - LS-C164466 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of Mapk13 (arrow) using rabbit polyclonal Mouse Mapk13 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Mapk13 gene.
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