| Gene Symbol |
Car2
|
| Entrez Gene |
12349
|
| Alt Symbol |
AI131712, CAII, Ca2, Car-2, Ltw-5, Lvtw-5
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
carbonic anhydrase 2
|
| Other Description |
CA II|CA-II|carbonate dehydratase II|carbonic anhydrase II
|
| Swissprots |
Q9DCY9 Q7TPE1 Q9DCT3 P00920 Q6LDQ7
|
| Accessions |
AAA37357 EDL05130 P00920 AK002333 BAB22019 AK002498 BAB22146 AK146015 BC044806 BC055291 AAH55291 BU946040 CD774528 K00811 AAA37356 M25944 AAA39505 U37705 U37706 XM_006530050 XP_006530113 NM_009801 NP_033931
|
| Function |
Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. {ECO:0000269|PubMed:20150244}.
|
| Subcellular Location |
Cytoplasm. Cell membrane {ECO:0000250}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity). {ECO:0000250}.
|
| Top Pathways |
Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion
|