| Gene Symbol | LIPA |
|---|---|
| Entrez Gene | 3988 |
| Alt Symbol | CESD, LAL |
| Species | Human |
| Gene Type | protein-coding |
| Description | lipase A, lysosomal acid, cholesterol esterase |
| Other Description | acid cholesteryl ester hydrolase|cholesterol ester hydrolase|cholesteryl esterase|lysosomal acid lipase|lysosomal acid lipase/cholesteryl ester hydrolase|sterol esterase |
| Swissprots | Q5T074 B2RBH5 Q96EJ0 Q53H21 D3DR29 Q16529 Q5T771 P38571 |
| Accessions | AAB60327 EAW50140 EAW50141 EAW50142 P38571 AK091558 BAG52380 AK096406 BAG53281 AK125193 BAC86078 AK130882 AK222760 BAD96480 AK290241 BAF82930 AK293491 BAG56978 AK297079 BAG59596 AK314665 BAG37222 AU135835 BC012287 AAH12287 CA435432 DA275550 DA394611 DA466221 HQ447241 ADQ31728 HY150944 M74775 AAA59519 S68069 AAB29185 U08464 AAB60328 X76488 CAA54026 Z31690 CAA83495 NM_000235 NP_000226 NM_001127605 NP_001121077 NM_001288979 NP_001275908 NR_110233 |
| Function | Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. |
| Subcellular Location | Lysosome. |
| Top Pathways | Lysosome, Steroid biosynthesis |