NTHL1

Gene Symbol NTHL1
Entrez Gene 4913
Alt Symbol NTH1, OCTS3, hNTH1
Species Human
Gene Type protein-coding
Description nth endonuclease III-like 1 (E. coli)
Other Description DNA glycoslyase/AP lyase|bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase|endonuclease III-like protein 1
Swissprots Q9BPX2 Q99794 Q99566 Q1MVR1 P78549
Accessions AAC34209 AAM11786 ADP92214 ADP92215 ADP92216 ADP92217 ADP92218 ADP92219 ADP92220 ADP92221 ADP92222 ADP92223 ADP92224 ADP92225 ADP92226 ADP92227 ADP92228 ADP92229 ADP92230 ADP92231 ADP92232 ADP92233 ADP92234 ADP92235 ADP92236 ADP92237 ADP92238 ADP92239 ADP92240 ADP92241 ADP92242 ADP92243 ADP92244 ADP92245 ADP92246 ADP92247 ADP92248 ADP92249 ADP92250 ADP92251 ADP92252 ADP92253 BAA32695 EAW85562 P78549 AB001575 BAA19413 BC000391 AAH00391 BC003014 AAH03014 U79718 AAB41534 U81285 AAC51136 Y09687 CAA70865 XM_011522505 XP_011520807 NM_002528 NP_002519
Function Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. {ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:11328882, ECO:0000269|PubMed:11380260, ECO:0000269|PubMed:11695910, ECO:0000269|PubMed:12140329, ECO:0000269|PubMed:12144783, ECO:0000269|PubMed:12519758, ECO:0000269|PubMed:14734554, ECO:0000269|PubMed:1553383
Subcellular Location Nucleus. Mitochondrion.
Tissue Specificity Widely expressed with highest levels in heart and lowest levels in lung and liver. {ECO:0000269|PubMed:8990169, ECO:0000269|PubMed:9831664}.
Top Pathways Base excision repair

NTH1 (A-12) - sc-22842 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NTH1 (A-12): sc-22842. Western blot analysis of NTH1 expression in HeLa whole cell lysate.

NTH1 (G-12) - sc-22843 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NTH1 (H-97) - sc-367354 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NTH1 (H-97): sc-367354. Western blot analysis of NTH1 expression in HEK293 whole cell lysate.

NTH1 (2660C1a) - sc-130644 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NTH1 (2660C1a): sc-130644. Western blot analysis of human recombinant NTH1 fusion protein.

Anti-NTH1 [EPR15930] antibody - ab191413 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15930
All lanes : Anti-NTH1 [EPR15930] antibody (ab191413) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : 293 cell lysateLane 3 : K562 cell lysateLane 4 : Human fetal heart lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/1000 dilution

Anti-NTH1 antibody - ab133901 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NTH1 antibody (ab133901) at 1 µg/ml + Human fetal lung lysate at 10 µg

Anti-NTH1 antibody - ab93 from Abcam

Prices $359.00
Sizes 220 µg
Host Rabbit
Clonality Polyclonal

Anti-NTH1 antibody [2660C1a] - ab70726 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2660C1a
All lanes : Anti-NTH1 antibody [2660C1a] (ab70726) at 0.2 µg/mlLane 1 : Whole cell lysate from human HEK293 cellsLane 2 : Whole cell lysate from mouse NIH3T3 cellsLane 3 : Whole cell lysate from rat F2408 cellsLysates/proteins at 25 µg per lane.

Anti-NTHL1 Antibody - LS-C9357 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody - LS-C37810 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody - LS-C73761 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-NTHL1 Antibody (Biotin) - LS-C140784 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody (DY650) - LS-C140785 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody (DY488) - LS-C140786 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody (HRP) - LS-C140787 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody (DY550) - LS-C140788 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody (clone 2660C1a) - LS-C184667 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2660C1a

Anti-NTHL1 Antibody (aa88-117, PE) - LS-C264822 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody (aa88-117, AP) - LS-C264820 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody (aa88-117, APC) - LS-C264821 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody (aa88-117, FITC) - LS-C264823 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody (aa95-126) - LS-C323468 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NTHL1 Antibody (aa91-140) - LS-C151665 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NTHL1 antibody Western Blot of Fetal Lung.

Anti-NTHL1 Antibody - LS-C2739 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of A549 cells using LS-C2739. A band is seen at 35 kD representing NTH1.

Anti-NTHL1 Antibody (aa88-117) - LS-C163033 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
NTHL1 Antibody (Center R103) western blot of HeLa,NCI-H460 cell line lysates (35 ug/lane). The NTHL1 antibody detected the NTHL1 protein (arrow).
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