NTHL1

Gene Symbol	NTHL1
Entrez Gene	4913
Alt Symbol	NTH1, OCTS3, hNTH1
Species	Human
Gene Type	protein-coding
Description	nth endonuclease III-like 1 (E. coli)
Other Description	DNA glycoslyase/AP lyase|bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase|endonuclease III-like protein 1
Swissprots	Q9BPX2 Q99794 Q99566 Q1MVR1 P78549
Accessions	AAC34209 AAM11786 ADP92214 ADP92215 ADP92216 ADP92217 ADP92218 ADP92219 ADP92220 ADP92221 ADP92222 ADP92223 ADP92224 ADP92225 ADP92226 ADP92227 ADP92228 ADP92229 ADP92230 ADP92231 ADP92232 ADP92233 ADP92234 ADP92235 ADP92236 ADP92237 ADP92238 ADP92239 ADP92240 ADP92241 ADP92242 ADP92243 ADP92244 ADP92245 ADP92246 ADP92247 ADP92248 ADP92249 ADP92250 ADP92251 ADP92252 ADP92253 BAA32695 EAW85562 P78549 AB001575 BAA19413 BC000391 AAH00391 BC003014 AAH03014 U79718 AAB41534 U81285 AAC51136 Y09687 CAA70865 XM_011522505 XP_011520807 NM_002528 NP_002519
Function	Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. {ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:11328882, ECO:0000269|PubMed:11380260, ECO:0000269|PubMed:11695910, ECO:0000269|PubMed:12140329, ECO:0000269|PubMed:12144783, ECO:0000269|PubMed:12519758, ECO:0000269|PubMed:14734554, ECO:0000269|PubMed:1553383
Subcellular Location	Nucleus. Mitochondrion.
Tissue Specificity	Widely expressed with highest levels in heart and lowest levels in lung and liver. {ECO:0000269|PubMed:8990169, ECO:0000269|PubMed:9831664}.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NTH1 full length protein - ab113607 from Abcam Category Protein Source E. coli Species Human

NTHL1 Antibody Blocking Peptide - LS-E1064 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NTHL1 Antibody Blocking Peptide - LS-E23427 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NTH1 Recombinant Protein - H00004913-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human NTH1 Protein - NBP1-72459 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

NTH1 Recombinant Protein - P5005 from Novus Biologicals Category Protein Prices $549.00 Sizes 50 µg Species Bacteria

NTHL1-Antibody-Center-R103-Blocking-peptide - BP11554c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human NTHL1 protein - orb168948 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

NTHL1 protein (His tag) - 80R-1973 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

NTH1 (1-312, His-tag) - AR50042PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

NTH1 (1-312, His-tag) - AR50042PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

NTH1 - H00004913-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

NTHL1, 1-312aa, Human, His tag, E.coli - 01-P1217 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

NTHL1 fusion protein - ag1631 from Proteintech Group Category Protein Source E. coli-derived, Species Human

NTHL1 fusion protein - Ag6536 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

NTHL1 fusion protein - Ag6734 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NTHL1 Human - ENPS-179 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Nth Endonuclease III-Like 1 Enzyme - BP002530-ENZ-172 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

NTHL1, 1-312aa, Recombinant Protein - GWB-P0821B from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

Recombinant Human Nth Endonuclease III-Like 1 (E. coli), His-tagged - NTHL1-2488H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human NTHL1, His-tagged - NTHL1-29928TH from Creative Biomart Category Protein Source E. coli

NTHL1 1-312aa - CMB-1050 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 50.00 µg, 250.00 µg Source E.coli Species Human

Recombinant Human Endonuclease III-like protein 1(NTHL1) - CSB-YP016125HU CSB-EP016125HU CSB-BP016125HU CSB-MP016125HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NTHL1, 1-312aa, Human, His tag, E.coli - ATGP1217 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

NTHL1 Protein - abx164919 from Abbexa Category Protein Species Human, Mouse, Rat

Search more