| Gene Symbol |
TP53BP1
|
| Entrez Gene |
7158
|
| Alt Symbol |
53BP1, p202, p53BP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor protein p53 binding protein 1
|
| Other Description |
p53-binding protein 1|tumor protein 53-binding protein, 1|tumor protein p53-binding protein, 1|tumor suppressor p53-binding protein 1
|
| Swissprots |
Q2M1Z7 Q7Z3U4 Q12888 Q5FWZ3 Q4LE46 F8VY86
|
| Accessions |
AAW69392 EAW92604 EAW92605 Q12888 AB210025 BAE06107 AF078776 AAC62018 AK123418 BAG53901 AK125173 AK292915 BAF85604 AK295764 BAH12183 AK307405 BC017846 AAH17846 BC063119 BC112161 AAI12162 BP228994 BX537418 CAD97660 U09477 AAA21596 XM_005254635 XP_005254692 XM_011521984 XP_011520286 XM_011521985 XP_011520287 XM_011521986 XP_011520288 XR_931898 XR_931899 NM_001141979 NP_001135451 NM_001141980 NP_001135452 NM_005657 NP_005648
|
| Function |
Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation. {ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed.
|
![Western Blot: 53BP1 Overexpression Lysate (Adult Normal) [NBP2-10450] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for 53BP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2794_53BP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10450-img0001.jpg)