STAT1

Gene Symbol	STAT1
Entrez Gene	6772
Alt Symbol	CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Species	Human
Gene Type	protein-coding
Description	signal transducer and activator of transcription 1, 91kDa
Other Description	signal transducer and activator of transcription 1, 91kD|signal transducer and activator of transcription 1-alpha/beta|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84
Swissprots	Q68D00 A8K989 Q53S88 Q53XW4 P42224 B2RCA0 Q9UDL5 D2KFR8 D3DPI7
Accessions	AAF04559 AAR13284 AAW56072 AAY24183 CAD22974 CAM91174 CAM91175 EAX10850 EAX10851 EAX10852 EAX10853 EAX10854 EAX10855 P42224 AI992149 AK096686 AK225853 AK292604 BAF85293 AK315002 BAG37497 BC002704 AAH02704 BC141921 AAI41922 BG699050 BT007241 AAP35905 BU738296 BX400908 CN410740 CR749636 CAH18430 CR998778 DA313984 EB385742 EU831980 ACE87421 EU832073 ACE86735 GU211347 ADA59516 GU211348 ADA59517 M97935 AAB64012 M97936 XM_006712718 XP_006712781 NM_007315 NP_009330 NM_139266 NP_644671
Function	Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN- stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral stat
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15322115}. Nucleus {ECO:0000269|PubMed:15322115}. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4.
Top Pathways	Prolactin signaling pathway, Tuberculosis, Herpes simplex infection, Osteoclast differentiation, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Stat1 siRNA I - 6331 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Stat1 siRNA II - 6544 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Stat1 p84/p91 CRISPR/Cas9 KO Plasmid (h) - sc-400086 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Stat1 p84/p91 HDR Plasmid (h) - sc-400086-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Stat1 p84/p91 Double Nickase Plasmid (h) - sc-400086-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Stat1 p84/p91 Double Nickase Plasmid (h2) - sc-400086-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Stat1 p84/p91 CRISPR Activation Plasmid (h) - sc-400086-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Stat1 p84/p91 CRISPR Activation Plasmid (h2) - sc-400086-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Stat1 p84/p91 Lentiviral Activation Particles (h) - sc-400086-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Stat1 p84/p91 Lentiviral Activation Particles (h2) - sc-400086-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Stat1 p84/p91 siRNA (h) - sc-44123 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Stat1 p84/p91 shRNA Plasmid (h) - sc-44123-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Stat1 p84/p91 shRNA (h) Lentiviral Particles - sc-44123-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

STAT1 RNAi - H00006772-R02 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU010121 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1542 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1542 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09848 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09848

STAT1 siRNA (Human) - CRH4629 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

STAT1 RNAi - H00006772-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

STAT1 - MBS8234584 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human STAT1 (NM_007315.3) - SHH419384 from Creative biogene Category siRNA Species Reactivities Human

STAT1 shRNA Plasmid (Human) - CHH4629 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

STAT1 miRNA 3'UTR clone - MiUTR3H-03470 from Creative biogene Species Reactivities Human

STAT1 miRNA 3'UTR clone - MiUTR3H-03471 from Creative biogene Species Reactivities Human

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