STAT1

Gene Symbol STAT1
Entrez Gene 6772
Alt Symbol CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Species Human
Gene Type protein-coding
Description signal transducer and activator of transcription 1, 91kDa
Other Description signal transducer and activator of transcription 1, 91kD|signal transducer and activator of transcription 1-alpha/beta|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84
Swissprots Q68D00 A8K989 Q53S88 Q53XW4 P42224 B2RCA0 Q9UDL5 D2KFR8 D3DPI7
Accessions AAF04559 AAR13284 AAW56072 AAY24183 CAD22974 CAM91174 CAM91175 EAX10850 EAX10851 EAX10852 EAX10853 EAX10854 EAX10855 P42224 AI992149 AK096686 AK225853 AK292604 BAF85293 AK315002 BAG37497 BC002704 AAH02704 BC141921 AAI41922 BG699050 BT007241 AAP35905 BU738296 BX400908 CN410740 CR749636 CAH18430 CR998778 DA313984 EB385742 EU831980 ACE87421 EU832073 ACE86735 GU211347 ADA59516 GU211348 ADA59517 M97935 AAB64012 M97936 XM_006712718 XP_006712781 NM_007315 NP_009330 NM_139266 NP_644671
Function Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN- stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral stat
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15322115}. Nucleus {ECO:0000269|PubMed:15322115}. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4.
Top Pathways Prolactin signaling pathway, Tuberculosis, Herpes simplex infection, Osteoclast differentiation, Inflammatory bowel disease (IBD)

PathScan ® Phospho-Stat1 (Tyr701) Sandwich ELISA Kit - 7234 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

STAT1 (pS727) + total STAT1 ELISA Kit - ab126455 from Abcam

Category ELISA Kit
Prices $499.00
Sizes 1 x 96 tests
A431 cells were treated with recombinant human EGF at 37°C for 20 min. Solubilize cells at 4 x 107 cells/ml in Cell Lysate Buffer. Serial dilutions of lysates were analyzed in this ELISA.

STAT1 (pS727) ELISA Kit - ab126454 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
A431 cells were treated with recombinant human EGF at 37°C for 20 min. Solubilize cells at 4 x 107 cells/ml in Cell Lysate Buffer. Serial dilutions of lysates were analyzed in this ELISA.

STAT1 (pY701) + total GAPDH PhosphoTracer ELISA Kit - ab119671 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
Using Western blot, STAT1 phosphorylation at Tyr701 is detected in interferon-gamma-treated HeLa cells (+), compared with untreated HeLa cells (-).

STAT1 (pY701) + total STAT1 ELISA Kit - ab126457 from Abcam

Category ELISA Kit
Prices $499.00
Sizes 1 x 96 tests
A431 cells were treated with recombinant human EGF at 37°C for 20 min. Solubilize cells at 4 x 107 cells/ml in Cell Lysate Buffer. Serial dilutions of lysates were analyzed in this ELISA.

STAT1 (pY701) ELISA Kit - ab126456 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
A431 cells were treated with recombinant Human EGF at 37&degC for 20 min. Solubilize cells at 4 x 107 cells/ml in Cell Lysate Buffer. Serial dilutions of lysates were analyzed using ab126456.

STAT1 (pY701) PhosphoTracer ELISA Kit - ab119649 from Abcam

Category ELISA Kit
Sensitivity 2000 cells/well
Range 2000 cells/well - 100000 cells/well
Using the STAT1 assay kit or Western blot, STAT1 phosphorylation at Tyr701 is detected in interferon-gamma-treated HeLa cells (+), compared with untreated HeLa cells (-).

STAT1 (pY701) SimpleStep ELISA™ Kit - ab176653 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Sensitivity < 20 µg/ml
Range 20 µg/ml - 2000 µg/ml
Example of a typical STAT1 (pY701) cell lysate dilution series. Raw data values are shown in the table. Background-subtracted data values (mean +/- SD) are graphed.

STAT1 (Tyr701) In-Cell ELISA Kit - ab126426 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
A431 cells were stimulated by different concentrations of EGF for 10 minutes at 37°C.  

Phosphotyrosine STAT1 ELISA Kit - RAB0994 from Sigma-Aldrich

Category ELISA Kit
Prices $637.00
Sizes 1 kt

Phospho-Stat1 (pTyr701) ELISA Kit - RAB0442 from Sigma-Aldrich

Category ELISA Kit
Prices $522.00
Sizes 1 kt

Phospho-Stat1 (pSer727) ELISA Kit - RAB0440 from Sigma-Aldrich

Category ELISA Kit
Prices $522.00
Sizes 1 kt

Mouse/Human/Rat STAT1 ELISA Kit (Cell-Based ELISA) - LS-F2326 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Human STAT1 ELISA Kit - LS-F4925 from LifeSpan Bioscience

Category ELISA Kit
Prices $690.00
Sizes 1 plate
Sensitivity 0.114 ng/ml
Range 0.313 - 20 ng/ml

Mouse/Human Phospho-STAT1 (Tyr701) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F948 from LifeSpan Bioscience

Category ELISA Kit
Prices $440.00, $820.00, $1,910.00
Sizes 1 plate, 2 plate, 5 plate

Mouse/Human/Rat STAT1 ELISA Kit (DNA-Binding ELISA) - LS-F803 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate

Mouse/Human/Rat Phospho-STAT1 (Ser727) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F914 from LifeSpan Bioscience

Category ELISA Kit
Prices $750.00
Sizes 1 plate

Mouse/Human/Rat Phospho-STAT1 (Tyr701) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F924 from LifeSpan Bioscience

Category ELISA Kit
Prices $750.00
Sizes 1 plate

Mouse/Human/Rat Phospho-STAT1 (Ser727) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1622 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-STAT1 (Tyr701) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1623 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse STAT1 ELISA Kit - LS-F9500 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity 0.127 ng/ml
Range 0.313 - 20 ng/ml

Human Phospho-STAT1 (Y701) Cell-Based ELISA - KCB2894 from R&D Systems

Category ELISA Kit
Prices $459.00
Sizes 1 kit

Signal transducer and activator of transcription 1-alpha/beta, STAT1, Human, ELISA Kit - E1740h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Signal Transducer and Activator of Transcription 1, STAT1, Human, ELISA Kit - E-EL-H2130 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL

Signal Transducer And Activator Of Transcription 1, STAT1, Mouse, ELISA Kit - E-EL-M1055 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL
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