TRIM28

Gene Symbol TRIM28
Entrez Gene 10155
Alt Symbol KAP1, PPP1R157, RNF96, TF1B, TIF1B
Species Human
Gene Type protein-coding
Description tripartite motif containing 28
Other Description E3 SUMO-protein ligase TRIM28|KAP-1|KRAB [Kruppel-associated box domain]-associated protein 1|KRAB-associated protein 1|KRAB-interacting protein 1|KRIP-1|RING finger protein 96|TIF1-beta|nuclear corepressor KAP-1|protein phosphatase 1, regulatory subunit 157|transcription intermediary factor 1-beta|transcriptional intermediary factor 1-beta|tripartite motif-containing 28|tripartite motif-containing protein 28
Swissprots Q13263 Q96IM1 Q7Z632 Q93040 O00677
Accessions EAW72605 EAW72606 EAW72607 Q13263 AK131063 AK225760 AK313478 BAG36262 AL360114 AL360188 AL360189 BC004978 AAH04978 BC007390 AAH07390 BC052986 AAH52986 U31657 AAA74954 U78773 AAB37341 U95040 AAB51517 X97548 CAA66150 NM_005762 NP_005753
Function Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity towar
Subcellular Location Nucleus {ECO:0000269|PubMed:10330177, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:9016654}. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1. {ECO:0000250}.
Tissue Specificity Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9016654}.

Rabbit anti-KAP-1 Antibody, Affinity Purified - PLA0078 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-KAP-1 Antibody, Affinity Purified: <B>Cat. No. PLA0078</B>: Detection of Human KAP-1 by Immunohistochemistry and Immunocytochemistry. Sample: FFPE section of Human prostate carcinoma (left) and formaldelyde-fixed HeLa cells (right). Antibody: Affinity purified Rabbit Anti-KAP-1 (Cat. No.<B>PLA0078</B>) used at a dilution of 1:1,000 (1 μg/mL).Detection: DAB (left) and green fluorescent goat Anti-Rabbit IgG highly cross-adsorbed Antibody FITC conjugated used at a dilution of 1:100 (right).

Rabbit anti-Phospho KAP-1 (S824) Antibody, Affinity Purified - PLA0140 from Sigma-Aldrich

Prices $345.00
Sizes 100 µl
<B>Immunocytochemistry</B><BR/>Rabbit Anti-Phospho KAP-1 (S824) Antibody, Affinity Purified: <B>Cat. No. PLA0140</B>: Detection of Human Phospho KAP-1 (S824) by Immunocytochemistry. Samples: NBF-fixed, asynchronous HeLa cells. Antibody: Affinity purified Rabbit Anti-Phospho KAP-1 (S824) (<B>Cat. No. PLA0140</B>) used at a dilution of 1:200 (1 μg/mL). Detection: Red fluorescent Anti-Rabbit IgG - DyLight<SUP>®</SUP> 594 conjugated used at a dilution of 1:100.

Goat anti-KAP-1 Antibody, Affinity Purified - PLA0295 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

Transcription intermediary factor 1-beta, TRIM28/KAP1/RNF96/TIF1B, ELISA Kit - MBS2602655 from MyBioSource

Category ELISA Kit
Prices $275.00, $420.00, $1,615.00, $2,880.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Up to 0.06 ng/ml.
Range 20 ng/ml-0.312 ng/ml

Human TRIM28/KAP1/RNF96/TIF1B ELISA Kit - E038860 from Biobool

Category ELISA Kit
Sensitivity Up to 0.06 ng/ml.

Human TIF1B ELISA Kit - E038877 from Biobool

Category ELISA Kit

Human TRIM28 ELISA Kit - E100337 from Biobool

Category ELISA Kit

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9344288 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9344197 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcription intermediary factor 1-beta (TRIM28/KAP1/RNF96/TIF1B), ELISA Kit - MBS2610173 from MyBioSource

Category ELISA Kit
Prices $300.00, $475.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9350699 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9349273 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcription intermediary factor 1-beta, ELISA Kit - MBS2607378 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9347958 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcription intermediary factor 1-beta, ELISA Kit - MBS2605547 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9355113 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9367433 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9359927 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9343816 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9363333 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcription intermediary factor 1-beta , ELISA Kit - MBS2606639 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9350590 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9359898 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcription intermediary factor 1-beta, ELISA Kit - MBS2604236 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcriptional Intermediary Factor 1 Beta (TIF1B), ELISA Kit - MBS9369304 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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