TRIM28

Gene Symbol	TRIM28
Entrez Gene	10155
Alt Symbol	KAP1, PPP1R157, RNF96, TF1B, TIF1B
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 28
Other Description	E3 SUMO-protein ligase TRIM28|KAP-1|KRAB [Kruppel-associated box domain]-associated protein 1|KRAB-associated protein 1|KRAB-interacting protein 1|KRIP-1|RING finger protein 96|TIF1-beta|nuclear corepressor KAP-1|protein phosphatase 1, regulatory subunit 157|transcription intermediary factor 1-beta|transcriptional intermediary factor 1-beta|tripartite motif-containing 28|tripartite motif-containing protein 28
Swissprots	Q13263 Q96IM1 Q7Z632 Q93040 O00677
Accessions	EAW72605 EAW72606 EAW72607 Q13263 AK131063 AK225760 AK313478 BAG36262 AL360114 AL360188 AL360189 BC004978 AAH04978 BC007390 AAH07390 BC052986 AAH52986 U31657 AAA74954 U78773 AAB37341 U95040 AAB51517 X97548 CAA66150 NM_005762 NP_005753
Function	Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity towar
Subcellular Location	Nucleus {ECO:0000269|PubMed:10330177, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:9016654}. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1. {ECO:0000250}.
Tissue Specificity	Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9016654}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KAP1 full length protein - ab131899 from Abcam Category Protein Source Wheat germ Species Human

Human KAP1 peptide - ab22963 from Abcam Category Peptide Species Human

Human KAP1 protein fragment - ab160846 from Abcam Category Protein Source Wheat germ Species Human

Human KAP1 protein fragment - ab195159 from Abcam Category Protein Source E. coli Species Human

Human KAP1 protein fragment - ab171679 from Abcam Category Protein Source E. coli Species Human

TRIM28 / KAP1 Antibody Blocking Peptide - LS-E1274 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM28 / KAP1 Antibody Blocking Peptide - LS-E25485 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM28 / KAP1 Antibody Blocking Peptide - LS-E11485 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM28 / KAP1 Antibody Blocking Peptide - LS-E10999 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM28 / KAP1 Antibody Blocking Peptide - LS-E13925 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM28 / KAP1 Antibody Blocking Peptide - LS-E29986 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

KAP1 Partial Recombinant Protein - H00010155-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human KAP1 Protein - H00010155-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human KAP1 Protein - NBP2-22889 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

TRIM28-Antibody-N-term-Blocking-peptide - BP11866a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KAP1 blocking peptide - GTX89879-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

Recombinant human Transcription intermediary factor 1-beta protein (OPCA00579) - OPCA00579 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human TRIM28 protein - orb245237 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

TRIM28 protein (His tag) - 80R-3031 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

KAP1 Peptide - AC21-0314-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TIF1-beta / TRIM28 (366-802, His-tag) - AR51149PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

TIF1-beta / TRIM28 (366-802, His-tag) - AR51149PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

TIF1-beta / TRIM28 - H00010155-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TIF1-beta / TRIM28 - H00010155-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TIF1-beta / TRIM28 - H00010155-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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