Gene Symbol | NR1H4 |
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Entrez Gene | 540528 |
Alt Symbol | - |
Species | Bovine |
Gene Type | protein-coding |
Description | nuclear receptor subfamily 1, group H, member 4 |
Other Description | bile acid receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|nuclear receptor subfamily 1 group H member 4 |
Swissprots | Q3SZL0 |
Accessions | DAA29555 Q3SZL0 BC102805 AAI02806 XM_005206661 XP_005206718 XM_005206662 XP_005206719 XM_005206663 XP_005206720 NM_001034708 NP_001029880 |
Function | Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Top Pathways | Bile secretion |
Recombinant Bovine Bile acid receptor(NR1H4) - CSB-YP666185BO CSB-EP666185BO CSB-BP666185BO CSB-MP666185BO from Cusabio
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Bile acid receptor (NR1H4), Recombinant Protein - MBS1283920 from MyBioSource
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