Got1
| Gene Symbol | Got1 |
|---|---|
| Entrez Gene | 24401 |
| Alt Symbol | Aspat, Gaspat, cAspAT, cCAT |
| Species | Rat |
| Gene Type | protein-coding |
| Description | glutamic-oxaloacetic transaminase 1, soluble |
| Other Description | aspartate aminotransferase 1|aspartate aminotransferase, cytoplasmic|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic|cytosolic aspartate aminotransferase|glutamate oxaloacetate transaminase 1, soluble|transaminase A |
| Swissprots | Q64570 P13221 Q6P721 |
| Accessions | AAA40842 CBF96063 CBF96226 CBV09583 CBV09746 EDL94253 EDL94254 P13221 BC061877 AAH61877 CB578328 CK600227 D00252 BAA00183 FM055803 FN802619 FQ219727 J04171 AAA40769 NM_012571 NP_036703 |
| Function | Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. {ECO:0000269|PubMed:17545671, ECO:0000269|PubMed:21266983, ECO:0000269|PubMed:21361730, ECO:0000269|PubMed:3053674, ECO:0000269|PubMed:3182750, ECO:0000269|PubMed:7113743}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expressed in liver and kidney. {ECO:0000269|PubMed:3182856}. |
| Top Pathways | Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Phenylalanine metabolism, Biosynthesis of amino acids, Tyrosine metabolism |
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