DKC1

Gene Symbol DKC1
Entrez Gene 1736
Alt Symbol CBF5, DKC, DKCX, NAP57, NOLA4, XAP101
Species Human
Gene Type protein-coding
Description dyskeratosis congenita 1, dyskerin
Other Description CBF5 homolog|H/ACA ribonucleoprotein complex subunit 4|nopp140-associated protein of 57 kDa|nucleolar protein NAP57|nucleolar protein family A member 4|snoRNP protein DKC1
Swissprots Q9Y505 O60832 Q96G67 F5BSB3 O43845
Accessions AAD20232 CAA11970 CAB39106 CAB51168 EAW72661 EAW72662 EAW72663 O60832 AF067008 AAD11815 AK225077 AK307672 AM392631 CAL37509 AM392823 CAL37701 BC009928 AAH09928 BC010015 AAH10015 BI858251 BU730947 CD367400 DA429806 DB517187 DQ892737 ABM83663 DQ895984 ABM86910 HY050100 JF279874 ADX66370 KC954523 AGZ20497 KC954524 AGZ20498 KC954525 AGZ20499 U59151 AAB94299 NM_001142463 NP_001135935 NM_001288747 NP_001275676 NM_001363 NP_001354 NR_110021 NR_110022 NR_110023
Function Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Subcellular Location Isoform 1: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10903840}.
Top Pathways Ribosome biogenesis in eukaryotes

Human-DKC1-cDNA-Clone - DC02810 from Abgent, a WuXi AppTec company

Prices $693.90
Sizes 10 µg
Species Human
Accession BC009928

DKC1 - MBS1270933 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC009928

DKC1 - MBS1274817 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC010015

Human DKC1 cDNA clone(NM_001142463.1) - CDFH005119 from Creative Biomart

Species Human
Accession NM_001142463.1

Human DKC1 ORF Clone(NM_001363.3) - CDCL161112 from Creative Biomart

Species Human
Accession NM_001363.3

Human DKC1 ORF Clone(NM_001142463.1) - CDCR351320 from Creative Biomart

Species Human
Accession NM_001142463.1

Human DKC1 ORF Clone(NM_001142463.1) - CDCR351321 from Creative Biomart

Species Human
Accession NM_001142463.1

Human DKC1 ORF clone (NM_001142463.1) - CDCR055746 from Creative biogene

Species Human

Human DKC1 ORF Clone (BC009928) - CDCS408273 from Creative biogene

Species Human
Accession O60832

Human DKC1 ORF Clone (BC010015) - CDCS408274 from Creative biogene

Species Human
Accession O60832

Human DKC1 cDNA Clone(NM_001142463.1) - CDFH005119 from Creative biogene

Species Human
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