ERN1

Gene Symbol ERN1
Entrez Gene 2081
Alt Symbol IRE1, IRE1P, IRE1a, hIRE1p
Species Human
Gene Type protein-coding
Description endoplasmic reticulum to nucleus signaling 1
Other Description ER to nucleus signalling 1|endoplasmic reticulum-to-nucleus signaling 1|inositol-requiring 1|inositol-requiring enzyme 1|inositol-requiring protein 1|ire1-alpha|protein kinase/endoribonuclease|serine/threonine-protein kinase/endoribonuclease IRE1
Swissprots A8K8N8 A1L457 A8MXS7 Q59EE2 O75460
Accessions EAW94213 EAW94214 O75460 AB209869 BAD93106 AF059198 AAC25991 AI791744 AI792619 AK055561 AK124426 AK292403 BAF85092 AL698247 BC070350 BC130405 AAI30406 BC130407 AAI30408 BF817483 BF846361 DB128514 NM_001433 NP_001424 NM_152461
Function Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. {ECO:0000250|UniProtKB:Q9EQY0, ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:9637683}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}.
Tissue Specificity Ubiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269|PubMed:9637683}.
Top Pathways Alzheimer's disease, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD)

ERN1 overexpression lysate - LY419940 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

Human ERN1 / IRE1 (aa 465-977) Insect Cell Lysate (WB positive control) - 11905-HNCBL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human ERN1 / IRE1 (aa 465-977) Insect Cell Lysate (WB positive control) - 11905-H20BL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human ERN1 (aa 465-977) Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175539 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Human ERN1 (aa 465-977) Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175593 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human ERN1 Knockdown Stable Cell Line - CSC-DC005059 from Creative biogene

Category Cell Line
Species Human

ERN1 Knockout Cell Line-HeLa - CSC-RT1766 from Creative biogene

Category Cell Line
Species Human

ERN1 KO Cell Lysate-HeLa - CLKO-1612 from Creative biogene

Category Cell Lysate
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