| Gene Symbol |
ERN1
|
| Entrez Gene |
2081
|
| Alt Symbol |
IRE1, IRE1P, IRE1a, hIRE1p
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
endoplasmic reticulum to nucleus signaling 1
|
| Other Description |
ER to nucleus signalling 1|endoplasmic reticulum-to-nucleus signaling 1|inositol-requiring 1|inositol-requiring enzyme 1|inositol-requiring protein 1|ire1-alpha|protein kinase/endoribonuclease|serine/threonine-protein kinase/endoribonuclease IRE1
|
| Swissprots |
A8K8N8 A1L457 A8MXS7 Q59EE2 O75460
|
| Accessions |
EAW94213 EAW94214 O75460 AB209869 BAD93106 AF059198 AAC25991 AI791744 AI792619 AK055561 AK124426 AK292403 BAF85092 AL698247 BC070350 BC130405 AAI30406 BC130407 AAI30408 BF817483 BF846361 DB128514 NM_001433 NP_001424 NM_152461
|
| Function |
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. {ECO:0000250|UniProtKB:Q9EQY0, ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:9637683}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}.
|
| Tissue Specificity |
Ubiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269|PubMed:9637683}.
|
| Top Pathways |
Alzheimer's disease, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD)
|