CNTN1

Gene Symbol	CNTN1
Entrez Gene	1272
Alt Symbol	F3, GP135, MYPCN
Species	Human
Gene Type	protein-coding
Description	contactin 1
Other Description	contactin-1|glycoprotein gP135|neural cell surface protein F3
Swissprots	Q7M4P0 A8K0Y3 Q8N466 Q14030 Q12860 Q12861 A8K0H9
Accessions	EAW57822 EAW57823 EAW57824 Q12860 AI473107 AK289544 BAF82233 AK289698 BAF82387 BC036569 AAH36569 BM717031 BX648591 BY799936 DA215712 DQ442053 DQ442054 U07819 AAA67920 U07820 AAA67921 Z21488 CAA79696 XM_005268651 XP_005268708 XM_006719241 XP_006719304 XM_011537926 XP_011536228 XM_011537927 XP_011536229 NM_001256063 NP_001242992 NM_001256064 NP_001242993 NM_001843 NP_001834 NM_175038 NP_778203
Function	Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). {ECO:0000250}.
Subcellular Location	Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side.
Tissue Specificity	Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle. {ECO:0000269|PubMed:2026173, ECO:0000269|PubMed:8164510}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CNTN1 overexpression lysate - LY406372 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

CNTN1 overexpression lysate - LY430423 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

CNTN1 293 Cell Lysate - 400681 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Contactin-1 Overexpression Lysate (Native) - NBL1-09333 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

CNTN1 Over-expression Lysate Product - GWB-6C7743 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human Coagulation Factor III / Tissue Factor / CD142 HEK293 Cell Lysate (WB positive control) - 13133-H08HL-300 from Sino Biological Category Tissue Lysate Prices $195.00 Sizes 300 µg Species Human

Human Coagulation Factor III / Tissue Factor / CD142 HEK293 Cell Lysate (WB positive control) - 13133-H02HL-300 from Sino Biological Category Tissue Lysate Prices $195.00 Sizes 300 µg Species Human

Human Contactin 1 / CNTN1 HEK293 Cell Lysate (WB positive control) - 10383-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CNTN1 Human Cells Transfected Lysate (positive control) (denatured) - orb172827 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Contactin-1 Overexpression Lysate (Native) - NBP2-05089 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human CNTN1 Knockdown Stable Cell Line - CSC-DC003401 from Creative biogene Category Cell Line Species Human

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