CCL22
| Gene Symbol | CCL22 |
|---|---|
| Entrez Gene | 6367 |
| Alt Symbol | A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 22 |
| Other Description | C-C motif chemokine 22|CC chemokine STCP-1|MDC(1-69)|macrophage-derived chemokine|small inducible cytokine A22|small inducible cytokine subfamily A (Cys-Cys), member 22|small-inducible cytokine A22|stimulated T cell chemotactic protein 1|stimulated T-cell chemotactic protein 1 |
| Swissprots | A0N0Q6 O00626 B2R4W2 |
| Accessions | AAC24306 ABK41947 EAW82918 O00626 AK311970 BAG34909 BC027952 AAH27952 DA815965 DB154173 DQ890922 ABM81848 DQ893311 ABM84237 DQ894072 ABM84998 DQ896625 ABM87624 EU176526 ABW03327 U83171 AAB58360 U83239 AAB53372 NM_002990 NP_002981 |
| Function | May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. {ECO:0000269|PubMed:11241286}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
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