CCL22

Gene Symbol	CCL22
Entrez Gene	6367
Alt Symbol	A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1
Species	Human
Gene Type	protein-coding
Description	chemokine (C-C motif) ligand 22
Other Description	C-C motif chemokine 22|CC chemokine STCP-1|MDC(1-69)|macrophage-derived chemokine|small inducible cytokine A22|small inducible cytokine subfamily A (Cys-Cys), member 22|small-inducible cytokine A22|stimulated T cell chemotactic protein 1|stimulated T-cell chemotactic protein 1
Swissprots	A0N0Q6 O00626 B2R4W2
Accessions	AAC24306 ABK41947 EAW82918 O00626 AK311970 BAG34909 BC027952 AAH27952 DA815965 DB154173 DQ890922 ABM81848 DQ893311 ABM84237 DQ894072 ABM84998 DQ896625 ABM87624 EU176526 ABW03327 U83171 AAB58360 U83239 AAB53372 NM_002990 NP_002981
Function	May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
Subcellular Location	Secreted.
Tissue Specificity	Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. {ECO:0000269|PubMed:11241286}.
Top Pathways	Cytokine-cytokine receptor interaction, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MDC full length protein - ab191737 from Abcam Category Protein Prices $192.00 Sizes 20 µg Source E. coli Species Human

Active MDC full length protein - ab638 from Abcam Category Protein Prices $239.00 Sizes 20 µg Source E. coli

Active MDC full length protein - ab9848 from Abcam Category Protein Prices $110.00, $257.00 Sizes 5 µg, 20 µg Source E. coli

Active mouse MDC full length protein - ab201393 from Abcam Category Protein Prices $101.00 Sizes 5 µg Source E. coli Species Mouse

Human MDC full length protein - ab87715 from Abcam Category Protein Source E. coli Species Human

Human MDC full length protein - ab175160 from Abcam Category Protein Source Synthetic Species Human

Human MDC full length protein - ab176040 from Abcam Category Protein Source Synthetic Species Human

Recombinant Human CCL22/MDC Protein - NBP2-34977 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

CCL22/MDC Recombinant Protein - H00006367-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CCL22/MDC Protein - NBP1-30245 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Species Human

CCL22-Antibody-Center-Blocking-Peptide - BP16351c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MDC Recombinant Protein (Active) - GTX48144-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

MDC Recombinant Protein (Active) - GTX48145-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

Recombinant Human CCL22/MDC - 336-MD-025 from R&D Systems Category Protein Source E. coli-derived, Gly25-Gln93

Recombinant Human CCL22/MDC, CF - 336-MD-025/CF from R&D Systems Category Protein Source E. coli-derived, Gly25-Gln93

Recombinant Mouse CCL22/MDC - 439-MD-025 from R&D Systems Category Protein Source E. coli-derived, Gly25-Ser92

Recombinant Mouse CCL22/MDC, CF - 439-MD-025/CF from R&D Systems Category Protein Source E. coli-derived, Gly25-Ser92

CCL22 Protein Lysate (APL10304) - APL10304 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Recombinant human C-C motif chemokine 22 (OPCA00608) - OPCA00608 from Aviva Systems Biology Category Protein Prices $198.00 Sizes 50 µg Species Human

MDC Protein (OPPA01827) - OPPA01827 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

MDC Protein (OPPA01979) - OPPA01979 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human CCL22 protein (His Tag) - orb138331 from Biorbyt Category Protein Prices $298.00, $434.00 Sizes 20 μg, 50 μg Source E. coli Species Human

Human CCL22 protein (His Tag) - orb80677 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human CCL22 protein - orb245259 from Biorbyt Category Protein Prices $315.00, $502.00, $782.00, $1,139.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

CCL22/MDC protein (His tag) - 80R-1202 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

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