NR3C2

Gene Symbol NR3C2
Entrez Gene 4306
Alt Symbol MCR, MLR, MR, NR3C2VIT
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 3, group C, member 2
Other Description aldosterone receptor|mineralocorticoid receptor|mineralocorticoid receptor 1|mineralocorticoid receptor delta
Swissprots B0ZBF5 B0ZBF7 Q96KQ9 P08235 Q2NKL1 Q96KQ8
Accessions AAY41033 ACA05923 ACA05924 ACA05926 ACS13715 ACS13716 ACS13718 EAX05008 P08235 AB209056 BAD92293 AJ315514 CAC67405 AJ315515 CAC67406 AK123047 AK304318 BAG65170 BC111758 AAI11759 BQ184536 DB061545 DB232659 M16801 AAA59571 XM_011531975 XP_011530277 XM_011531976 XP_011530278 XM_011531977 XP_011530279 XM_011531978 XP_011530280 NM_000901 NP_000892 NM_001166104 NP_001159576
Function Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}.
Subcellular Location Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Tissue Specificity Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. {ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:9141514}.
Top Pathways Aldosterone-regulated sodium reabsorption

Mineralocorticoid R/NR3C2 Overexpression Lysate (Native) - NBP2-10715 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg

Panoply™ Human NR3C2 Knockdown Stable Cell Line - CSC-DC010601 from Creative biogene

Category Cell Line
Species Human
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