UBE2S

Gene Symbol	UBE2S
Entrez Gene	27338
Alt Symbol	E2-EPF, E2EPF, EPF5
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2S
Other Description	E2-EPF5|ubiquitin carrier protein S|ubiquitin-conjugating enzyme E2 S|ubiquitin-conjugating enzyme E2-24 kD|ubiquitin-conjugating enzyme E2-24 kDa|ubiquitin-conjugating enzyme E2-EPF5|ubiquitin-protein ligase S
Swissprots	Q16763 Q9BTC1
Accessions	ABC40675 EAW72377 Q16763 AB062397 BAB93484 BC004236 AAH04236 BC007554 AAH07554 BC065364 AAH65364 BC066948 AAH66948 CA421746 CN305224 HQ448521 ADQ33000 M91670 AAA58446 XM_011526752 XP_011525054 XM_011526753 XP_011525055 NM_014501 NP_055316
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human UBE2S full length protein - ab188709 from Abcam Category Protein Prices $276.00 Sizes 50 µg Source E. coli Species Human

Human UBE2S full length protein - ab87756 from Abcam Category Protein Source E. coli Species Human

Human UBE2S peptide - ab23035 from Abcam Category Peptide Species Human

UBE2S protein (Human) - ab127394 from Abcam Category Protein Source E. coli Species Human

UBE2S / E2 EPF Antibody Blocking Peptide - LS-E25471 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2S / E2 EPF Antibody Blocking Peptide - LS-E15891 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2S / E2 EPF Antibody Blocking Peptide - LS-E6867 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2S / E2 EPF Antibody Blocking Peptide - LS-E6868 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2S Recombinant Protein - H00027338-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UBE2S Protein - NBP1-30208 from Novus Biologicals Category Protein Prices $249.00 Sizes 100 µg Species Human

UBE2S Peptide - P0896 from Novus Biologicals Category Peptide Species Human

UBE2S Peptide - P0895 from Novus Biologicals Category Peptide Species Human

E2EPF-Antibody-C-term-Blocking-Peptide - BP2120b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

E2EPF-Antibody-N-term-Blocking-Peptide - BP2120a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2S blocking peptide - GTX89801-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Recombinant Human His6UBE2S, CF - E2-690-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

Recombinant Human His6UBE2S, CF - E2-690-100 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

UBE2S Protein (OPPA02051) - OPPA02051 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

UBE2S Blocking Peptide - 33R-6884 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBE2S protein (His tag) - 80R-1188 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

UBE2S Peptide - AC21-0300-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UBE2S (1-222, His-tag) - AR09255PU-L from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

UBE2S (1-222, His-tag) - AR09255PU-N from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

UBE2S - H00027338-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBE2S - H00027338-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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