CRYAA

Gene Symbol CRYAA
Entrez Gene 1409
Alt Symbol CRYA1, CTRCT9, HSPB4
Species Human
Gene Type protein-coding
Description crystallin, alpha A
Other Description alpha-crystallin A chain|crystallin, alpha-1|heat shock protein beta-4|human alphaA-crystallin (CRYA1)
Swissprots Q53X53 P02489
Accessions AAA52105 AAA52106 AAB21309 AAB33370 AAB99912 BAA95535 EAX09497 EAX09498 P02489 BC069528 AAH69528 BC113598 AAI13599 BE552434 BM679139 BX118596 CR407691 CAG28619 HQ258067 ADR82821 HQ448434 ADQ32914 L25781 AAC37570 U05569 AAA97523 U66584 AAC50900 X14789 CAA32891 XM_005261093 XP_005261150 NM_000394 NP_000385
Function Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. {ECO:0000269|PubMed:22120592}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus {ECO:0000269|PubMed:19464326}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Tissue Specificity Expressed in eye lens. {ECO:0000269|PubMed:12356833}.
Top Pathways Protein processing in endoplasmic reticulum

αA-crystallin (B-2) - sc-28306 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
αA-crystallin (B-2): sc-28306. Immunofluorescence staining of methanol-fixed Y79 cells showing cytoplasmic localization.

αA-crystallin (C-20) - sc-22389 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
αA-crystallin (C-20): sc-22389. Western blot analysis of human recombinant αA-crystallin fusion protein.

αA-crystallin (FL-173) - sc-22743 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
αA-crystallin (FL-173): sc-22743. Western blot analysis of αA-crystallin expression in mouse eye (A) and rat eye (B) tissue extracts.

αA-crystallin (H-4) - sc-398304 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
αA-crystallin (H-4): sc-398304. Western blot analysis of αA-crystallin expression in human eye tissue extract.

αA-crystallin (G-20) - sc-22388 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
αA-crystallin (G-20): sc-22388. Western blot analysis of αA-crystallin expression in rat eye (A) and mouse eye (B) tissue extracts.

αA-crystallin (SUB4) - sc-69687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
αA-crystallin (SUB4): sc-69687. Western blot analysis of αA-crystallin expression in Y79 (A), ARPE-19 (B) and U-87 MG (C) whole cell lysates.

Anti-Alpha A + alpha B Crystallin antibody - ab28163 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Alpha A + alpha B Crystallin antibody (ab28163) at 1/1000 dilutionLane 1 : Tissue lysates prepared from mouse heartLane 2 : Cell lysates prepared from Hela cellsLane 3 : Crystallin alpha B native bovine protein Lane 4 : Crystallin alpha native bovine proteinLane 5 : Molecular weight marker

Anti-alpha A + alpha B Crystallin antibody - ab63998 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Ab63998 (1:2000) staining of human brain tissue showing aß crystallin accumulation in Rosenthal fibres. Secondary antibody biotinylated Goat anti-rabbit (1/2000). (A) Shows the early stages of aß crystallin accumulation in astrocytes, (B) astrocyte begins to hypertrophy with aß crystallin accumulation, (C) the astrocyte begins to further hypertrophy and cell structure is lost.

Anti-alpha A Crystallin antibody - ab101189 from Abcam

Prices $372.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

Anti-alpha A Crystallin antibody - ab139503 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-alpha A Crystallin antibody (ab139503) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissueLane 2 : Spinal Cord (Human) Tissue Lysate - adult normal tissueLysates/proteins at 10 µg per lane.SecondaryDonkey Anti-Rabbit IgG H&L preadsorbed (ab97081) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-alpha A Crystallin antibody - ab156212 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-alpha A Crystallin antibody (ab156212) at 1/100 dilution + HepG2 cell lysate at 35 µg

Anti-alpha A Crystallin antibody [c9F2] - ab14821 from Abcam

Prices $373.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone c9F2

Anti-alpha A Crystallin antibody [EPR14125(B)] - ab181866 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14125(B)
Immunofluorescence analysis of Y79 cells fixed with acetone labeling alpha A Crystallin with ab181866 at 1/500 dilution followed by Goat anti rabbit IgG(Alexa Fluor®555) at 1/200 dilution and counterstained with Dapi.

Anti-CRYAA / Alpha A Crystallin Antibody (clone 3B12) - LS-C337920 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 3B12
IHC of paraffin-embedded Human prostate tissue using anti-CRYAA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-CRYAA / Alpha A Crystallin Antibody - LS-C22442 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRYAA / Alpha A Crystallin Antibody - LS-C22441 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRYAA / Alpha A Crystallin Antibody - LS-C22445 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CRYAA / Alpha A Crystallin Antibody - LS-C45026 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CRYAA / Alpha A Crystallin Antibody - LS-C63914 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CRYAA / Alpha A Crystallin Antibody (clone 1H3.B8, Atto 565) - LS-C231234 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1H3.B8

Anti-CRYAA / Alpha A Crystallin Antibody (clone 1H3.B8, Atto 390) - LS-C231232 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1H3.B8

Anti-CRYAA / Alpha A Crystallin Antibody (clone 1H3.B8, Atto 488) - LS-C231233 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1H3.B8

Anti-CRYAA / Alpha A Crystallin Antibody (clone 1H3.B8, Atto 633) - LS-C231235 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1H3.B8

Anti-CRYAA / Alpha A Crystallin Antibody (clone 1H3.B8, Atto 594) - LS-C231236 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1H3.B8

Anti-CRYAA / Alpha A Crystallin Antibody (clone C9F2) - LS-C93712 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone C9F2
Rat eye extracts were resolved by electrophoresis, transferred to PVDF membrane and probed with anti-crystallin a?(1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a DAP detection system. Arrow indicates crystalline a?(~20 kD). This antibody is not shown cross-activity.
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