JUP

Gene Symbol JUP
Entrez Gene 3728
Alt Symbol ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB
Species Human
Gene Type protein-coding
Description junction plakoglobin
Other Description catenin (cadherin-associated protein), gamma 80kDa|desmoplakin III|desmoplakin-3
Swissprots Q9BWC4 Q9HCX9 Q7L3S5 Q15151 P14923 Q86W21 Q15093
Accessions AAG16727 BAA09435 CAC04246 CAP07504 CAP11472 CAR97086 CAT82323 CCQ43676 EAW60762 EAW60763 EAW60764 EAW60765 P14923 AK226051 AY243535 AAO85780 BC000441 AAH00441 BC011865 AAH11865 DQ891420 ABM82346 DQ894594 ABM85520 M23410 AAA64895 Z68228 CAA92522 XM_006721873 XP_006721936 XM_006721874 XP_006721937 XM_006721875 XP_006721938 XM_006721878 XP_006721941 XM_011524753 XP_011523055 XM_011524754 XP_011523056 XM_011524755 XP_011523057 XM_011524756 XP_011523058 XM_011524757 XP_011523059 XM_011524758 XP_011523060 NM_002230 NP_002221 NM_021991 NP_068831
Function Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}.
Subcellular Location Cell junction, adherens junction {ECO:0000269|PubMed:22781308}. Cell junction, desmosome {ECO:0000269|PubMed:22781308}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22781308}. Membrane {ECO:0000269|PubMed:22781308}; Peripheral membrane protein {ECO:0000269|PubMed:22781308}. Note=Cytoplasmic in a soluble and membrane-associated form.
Top Pathways Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Transcriptional misregulation in cancer

Human JUP gene - orb92122 from Biorbyt

Prices $408.00
Sizes 10 μg
Species Human

JUP - MBS1268831 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC011865

Human JUP ORF clone(NM_002230.2) - CDCL185017 from Creative Biomart

Species Human
Accession NM_002230.2

Human JUP Gene cDNA Clone (full-length ORF Clone) - HG12020-G from Sino Biological

Species Human
Accession NM_002230.2

Human JUP natural ORF mammalian expression plasmid, N-His tag - HG12020-NH from Sino Biological

Species Human
Accession XM_006721878.1

Human JUP natural ORF mammalian expression plasmid, C-GFPSpark tag - HG12020-ACG from Sino Biological

Species Human
Accession XM_006721878.1

Human JUP natural ORF mammalian expression plasmid, N-GFPSpark tag - HG12020-ANG from Sino Biological

Species Human
Accession XM_006721878.1

Human JUP natural ORF mammalian expression plasmid, N-HA tag - HG12020-NY from Sino Biological

Species Human
Accession XM_006721878.1

Human JUP natural ORF mammalian expression plasmid, C-OFPSpark tag - HG12020-ACR from Sino Biological

Species Human
Accession XM_006721878.1

Human JUP natural ORF mammalian expression plasmid, N-OFPSpark tag - HG12020-ANR from Sino Biological

Species Human
Accession XM_006721878.1

Human JUP ORF clone(NM_002230.2) - CDCL185017 from Creative biogene

Species Human

Human JUP ORF Clone (BC011865) - CDCS410695 from Creative biogene

Species Human
Accession P14923
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