JUP

Gene Symbol	JUP
Entrez Gene	3728
Alt Symbol	ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB
Species	Human
Gene Type	protein-coding
Description	junction plakoglobin
Other Description	catenin (cadherin-associated protein), gamma 80kDa|desmoplakin III|desmoplakin-3
Swissprots	Q9BWC4 Q9HCX9 Q7L3S5 Q15151 P14923 Q86W21 Q15093
Accessions	AAG16727 BAA09435 CAC04246 CAP07504 CAP11472 CAR97086 CAT82323 CCQ43676 EAW60762 EAW60763 EAW60764 EAW60765 P14923 AK226051 AY243535 AAO85780 BC000441 AAH00441 BC011865 AAH11865 DQ891420 ABM82346 DQ894594 ABM85520 M23410 AAA64895 Z68228 CAA92522 XM_006721873 XP_006721936 XM_006721874 XP_006721937 XM_006721875 XP_006721938 XM_006721878 XP_006721941 XM_011524753 XP_011523055 XM_011524754 XP_011523056 XM_011524755 XP_011523057 XM_011524756 XP_011523058 XM_011524757 XP_011523059 XM_011524758 XP_011523060 NM_002230 NP_002221 NM_021991 NP_068831
Function	Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}.
Subcellular Location	Cell junction, adherens junction {ECO:0000269|PubMed:22781308}. Cell junction, desmosome {ECO:0000269|PubMed:22781308}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22781308}. Membrane {ECO:0000269|PubMed:22781308}; Peripheral membrane protein {ECO:0000269|PubMed:22781308}. Note=Cytoplasmic in a soluble and membrane-associated form.
Top Pathways	Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human gamma Catenin (phospho Y550) peptide - ab42715 from Abcam Category Peptide Species Human

Human gamma Catenin full length protein - ab114407 from Abcam Category Protein Source Wheat germ Species Human

Human gamma Catenin peptide - ab23208 from Abcam Category Peptide Species Human

JUP/CTNNG/Junction Plakoglobin Antibody Blocking Peptide - LS-E25379 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JUP/CTNNG/Junction Plakoglobin Antibody Blocking Peptide - LS-E9889 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human gamma Catenin Protein - H00003728-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

JUP-Antibody-C-term-Blocking-Peptide - BP8993b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

gamma Catenin blocking peptide - GTX11799-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat

JUP peptide - orb217501 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse

Gamma Catenin Peptide - AC21-0207-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Junction plakoglobin - H00003728-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Junction plakoglobin - H00003728-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

JUP Peptide - 45-076P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat

JUP fusion protein - ag17560 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

JUP fusion protein - Ag1627 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Recombinant Human JUP protein, GST-tagged - JUP-27307TH from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Junction Plakoglobin (JUP) - RPC196Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Gamma-catenin Blocking Peptide - CBP1638 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Rabbit

Catenin-γ (731) Peptide - BS1042P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Junction plakoglobin(JUP) - CSB-YP011975HU CSB-EP011975HU CSB-BP011975HU CSB-MP011975HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Junction plakoglobin (transcript variant 1) - TP304209 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Plakoglobin/Gamma-catenin, Peptide - MBS425039 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig

gamma Catenin Recombinant Protein Antigen - NBP2-33965PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

JUP Peptide, Human - M34GP07881H from Creative Peptides Category Peptide Source Synthetic. Species Human

Junction plakoglobin (JUP), Recombinant Protein - MBS963753 from MyBioSource Category Protein Prices $1,570.00, $1,570.00, $1,800.00, $1,800.00, $2,635.00, $2,635.00, $3,095.00, $3,095.00, $3,095.00, $5,215.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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