| Gene Symbol |
Mllt4
|
| Entrez Gene |
17356
|
| Alt Symbol |
5033403D15Rik, AF6, Af-6, Afadin, Gm314, I-afadin, S-afadin
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
|
| Other Description |
afadin|myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog|protein Af-6
|
| Swissprots |
Q9QZQ1
|
| Accessions |
Q9QZQ1 AF172447 AAD54283 AK016557 AK048179 AK077278 AK166398 BAE38754 BC026648 BC160377 AAI60377 BI991173 BQ929757 BU611478 CB181965 CF538789 CJ165098 CK637291 CN529812 CN537179 CN538841 CO042367 CO433521 XM_006523752 XP_006523815 XM_006523753 XP_006523816 XM_006523754 XP_006523817 XM_006523755 XP_006523818 XM_006523756 XP_006523819 XM_006523757 XP_006523820 XM_006523758 XP_006523821 XM_006523759 XP_006523822 XM_006523760 XP_006523823 XM_006523762 XP_006523825 XM_006523763 XP_006523826 XM_006523764 XP_006523827 XM_006523765 XP_006523828 XM_006523766 XP_006523829 XM_006523767 XP_006523830 XR_385293 XR_385294 NM_010806 NP_034936
|
| Function |
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. {ECO:0000269|PubMed:10477764}.
|
| Subcellular Location |
Cell junction, adherens junction. Note=Not found at cell-matrix AJs.
|
| Tissue Specificity |
Isoform 1 is expressed only in a restricted set of epithelial structures during early embryogenesis. {ECO:0000269|PubMed:10477764}.
|
| Top Pathways |
Adherens junction, Tight junction, Leukocyte transendothelial migration, cAMP signaling pathway, Rap1 signaling pathway
|