| Gene Symbol | Mllt4 |
|---|---|
| Entrez Gene | 17356 |
| Alt Symbol | 5033403D15Rik, AF6, Af-6, Afadin, Gm314, I-afadin, S-afadin |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 |
| Other Description | afadin|myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog|protein Af-6 |
| Swissprots | Q9QZQ1 |
| Accessions | Q9QZQ1 AF172447 AAD54283 AK016557 AK048179 AK077278 AK166398 BAE38754 BC026648 BC160377 AAI60377 BI991173 BQ929757 BU611478 CB181965 CF538789 CJ165098 CK637291 CN529812 CN537179 CN538841 CO042367 CO433521 XM_006523752 XP_006523815 XM_006523753 XP_006523816 XM_006523754 XP_006523817 XM_006523755 XP_006523818 XM_006523756 XP_006523819 XM_006523757 XP_006523820 XM_006523758 XP_006523821 XM_006523759 XP_006523822 XM_006523760 XP_006523823 XM_006523762 XP_006523825 XM_006523763 XP_006523826 XM_006523764 XP_006523827 XM_006523765 XP_006523828 XM_006523766 XP_006523829 XM_006523767 XP_006523830 XR_385293 XR_385294 NM_010806 NP_034936 |
| Function | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. {ECO:0000269|PubMed:10477764}. |
| Subcellular Location | Cell junction, adherens junction. Note=Not found at cell-matrix AJs. |
| Tissue Specificity | Isoform 1 is expressed only in a restricted set of epithelial structures during early embryogenesis. {ECO:0000269|PubMed:10477764}. |
| Top Pathways | Adherens junction, Tight junction, Leukocyte transendothelial migration, cAMP signaling pathway, Rap1 signaling pathway |
AF-6 CRISPR/Cas9 KO Plasmid (m) - sc-421663 from Santa Cruz Biotechnology
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AF-6 HDR Plasmid (m) - sc-421663-HDR from Santa Cruz Biotechnology
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AF-6 Double Nickase Plasmid (m) - sc-421663-NIC from Santa Cruz Biotechnology
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AF-6 Double Nickase Plasmid (m2) - sc-421663-NIC-2 from Santa Cruz Biotechnology
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AF-6 CRISPR Activation Plasmid (m) - sc-421663-ACT from Santa Cruz Biotechnology
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AF-6 CRISPR Activation Plasmid (m2) - sc-421663-ACT-2 from Santa Cruz Biotechnology
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AF-6 Lentiviral Activation Particles (m) - sc-421663-LAC from Santa Cruz Biotechnology
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AF-6 Lentiviral Activation Particles (m2) - sc-421663-LAC-2 from Santa Cruz Biotechnology
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AF-6 siRNA (m) - sc-43008 from Santa Cruz Biotechnology
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AF-6 shRNA Plasmid (m) - sc-43008-SH from Santa Cruz Biotechnology
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AF-6 shRNA (m) Lentiviral Particles - sc-43008-V from Santa Cruz Biotechnology
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MISSION® Long Non-Coding esiRNA - EMNC006971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN35622 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35622 from Sigma-Aldrich
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MLLT4 siRNA (Mouse) - CRM2550 from Cohesion Biosciences
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shRNA set against Mouse MLLT4 (NM_010806.1) - SHH342616 from Creative biogene
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Mouse MLLT4 siRNA - orb282026 from Biorbyt
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MLLT4 shRNA Plasmid (Mouse) - CHM2550 from Cohesion Biosciences
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