| Gene Symbol | HSD3B2 |
|---|---|
| Entrez Gene | 3284 |
| Alt Symbol | HSD3B, HSDB, SDR11E2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
| Other Description | 3 beta-HSD type II|3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II|3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2|3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II|3-beta-HSD II|3-beta-HSD adrenal and gonadal type|3-beta-hydroxy-5-ene steroid dehydrogenase|3-beta-hydroxy-Delta(5)-steroid dehydrogenase|delta 5-delta 4-isomerase type II|progesterone reductase|short chain dehydrogenase/reductase family 11E, member 2 |
| Swissprots | Q9UD08 Q6AI10 A2RRA5 Q53GD4 P26439 Q16010 Q99890 Q6LDB9 |
| Accessions | AAA36014 AAC60599 AAC60600 AAD14930 AJF45348 EAW56700 EAW56701 EAW56702 P26439 AK222997 BAD96717 AK313413 BAG36207 AV705363 BC038419 AAH38419 BC131488 AAI31489 BP197992 CF596786 DQ891764 ABM82690 DQ894948 ABM85874 M67466 AAA36016 NM_000198 NP_000189 NM_001166120 NP_001159592 |
| Function | 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. |
| Tissue Specificity | Expressed in adrenal gland, testis and ovary. |
| Top Pathways | Steroid hormone biosynthesis, Ovarian steroidogenesis |